Efficacy of Dissolvable Microneedle Patches with Skincare Actives in Acne Management: A Monocentric Clinical Trial
Background: Dissolvable Microneedle Patches (DMP) have emerged as a promising approach for improved topical delivery of skincare agents with dermatological values (dermo-cosmetics), effectively addressing the various skin concerns. These patches enable minimally invasive penetration of the skin’s ou...
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MDPI AG
2025-05-01
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| author | Muhammet Avcil Jens Klokkers Dohyeon Jeong Ayhan Celik |
| author_facet | Muhammet Avcil Jens Klokkers Dohyeon Jeong Ayhan Celik |
| author_sort | Muhammet Avcil |
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| description | Background: Dissolvable Microneedle Patches (DMP) have emerged as a promising approach for improved topical delivery of skincare agents with dermatological values (dermo-cosmetics), effectively addressing the various skin concerns. These patches enable minimally invasive penetration of the skin’s outer layer, facilitating efficient transdermal delivery of actives by overcoming skin barrier for successful outcomes. Objectives: The aim of this work was to assess the efficacy and safety of hyaluronic acid-based microneedle patches (HA-MNP) with agents for the managements of an inflammatory disorder of acne. A particular focus was on helping individuals with moderate inflammatory acne. Methods: A single-center clinical trial was conducted over a period of four weeks on acne patients. Measurable skin properties, including sebum content, redness, and severity of inflammation, were evaluated to gauge the overall usefulness of the MN patches. Results: The application of the patches resulted in a significant decrease in sebum content, with reductions of −4.9% and −36.8% observed after two and four weeks of use, respectively. The redness of localized acne lesions also showed a marked decline, with reductions of −47.2% and −65.5% observed after two and four weeks of use, respectively. Additionally, the severity of inflammatory signs in acne lesions showed significant improvements, with reductions of −68.8% and −83.3% observed for the application periods. The patches utilized in this investigation exhibited highly encouraging results, displaying a notable synergistic effect in the context of combating acne without adverse effects. Conclusions: The patches have the potential to be broadly applied as a modular and adaptable approach for therapeutic delivery of actives for various skin diseases and concerns. |
| format | Article |
| id | doaj-art-7e007ce5aeee4009957678a6165baeaf |
| institution | Kabale University |
| issn | 2673-8449 |
| language | English |
| publishDate | 2025-05-01 |
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| series | Biologics |
| spelling | doaj-art-7e007ce5aeee4009957678a6165baeaf2025-08-20T03:26:15ZengMDPI AGBiologics2673-84492025-05-01521510.3390/biologics5020015Efficacy of Dissolvable Microneedle Patches with Skincare Actives in Acne Management: A Monocentric Clinical TrialMuhammet Avcil0Jens Klokkers1Dohyeon Jeong2Ayhan Celik3Imperial Bioscience Ltd., London W4 5YA, UKDermatest GmbH, 48143 Münster, GermanyRaphas Co., Ltd., Seoul 07793, Republic of KoreaImperial Bioscience Ltd., London W4 5YA, UKBackground: Dissolvable Microneedle Patches (DMP) have emerged as a promising approach for improved topical delivery of skincare agents with dermatological values (dermo-cosmetics), effectively addressing the various skin concerns. These patches enable minimally invasive penetration of the skin’s outer layer, facilitating efficient transdermal delivery of actives by overcoming skin barrier for successful outcomes. Objectives: The aim of this work was to assess the efficacy and safety of hyaluronic acid-based microneedle patches (HA-MNP) with agents for the managements of an inflammatory disorder of acne. A particular focus was on helping individuals with moderate inflammatory acne. Methods: A single-center clinical trial was conducted over a period of four weeks on acne patients. Measurable skin properties, including sebum content, redness, and severity of inflammation, were evaluated to gauge the overall usefulness of the MN patches. Results: The application of the patches resulted in a significant decrease in sebum content, with reductions of −4.9% and −36.8% observed after two and four weeks of use, respectively. The redness of localized acne lesions also showed a marked decline, with reductions of −47.2% and −65.5% observed after two and four weeks of use, respectively. Additionally, the severity of inflammatory signs in acne lesions showed significant improvements, with reductions of −68.8% and −83.3% observed for the application periods. The patches utilized in this investigation exhibited highly encouraging results, displaying a notable synergistic effect in the context of combating acne without adverse effects. Conclusions: The patches have the potential to be broadly applied as a modular and adaptable approach for therapeutic delivery of actives for various skin diseases and concerns.https://www.mdpi.com/2673-8449/5/2/15microneedle patchacne vulgarisclinical studydermo-cosmetics |
| spellingShingle | Muhammet Avcil Jens Klokkers Dohyeon Jeong Ayhan Celik Efficacy of Dissolvable Microneedle Patches with Skincare Actives in Acne Management: A Monocentric Clinical Trial Biologics microneedle patch acne vulgaris clinical study dermo-cosmetics |
| title | Efficacy of Dissolvable Microneedle Patches with Skincare Actives in Acne Management: A Monocentric Clinical Trial |
| title_full | Efficacy of Dissolvable Microneedle Patches with Skincare Actives in Acne Management: A Monocentric Clinical Trial |
| title_fullStr | Efficacy of Dissolvable Microneedle Patches with Skincare Actives in Acne Management: A Monocentric Clinical Trial |
| title_full_unstemmed | Efficacy of Dissolvable Microneedle Patches with Skincare Actives in Acne Management: A Monocentric Clinical Trial |
| title_short | Efficacy of Dissolvable Microneedle Patches with Skincare Actives in Acne Management: A Monocentric Clinical Trial |
| title_sort | efficacy of dissolvable microneedle patches with skincare actives in acne management a monocentric clinical trial |
| topic | microneedle patch acne vulgaris clinical study dermo-cosmetics |
| url | https://www.mdpi.com/2673-8449/5/2/15 |
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