CD4+T Cells: Differentiation and Functions
CD4+T cells are crucial in achieving a regulated effective immune response to pathogens. Naive CD4+T cells are activated after interaction with antigen-MHC complex and differentiate into specific subtypes depending mainly on the cytokine milieu of the microenvironment. Besides the classical T-helper...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/925135 |
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| _version_ | 1850213733629952000 |
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| author | Rishi Vishal Luckheeram Rui Zhou Asha Devi Verma Bing Xia |
| author_facet | Rishi Vishal Luckheeram Rui Zhou Asha Devi Verma Bing Xia |
| author_sort | Rishi Vishal Luckheeram |
| collection | DOAJ |
| description | CD4+T cells are crucial in achieving a regulated effective immune response to pathogens. Naive CD4+T cells are activated after interaction with antigen-MHC complex and differentiate into specific subtypes depending mainly on the cytokine milieu of the microenvironment. Besides the classical T-helper 1 and T-helper 2, other subsets have been identified, including T-helper 17, regulatory T cell, follicular helper T cell, and T-helper 9, each with a characteristic cytokine profile. For a particular phenotype to be differentiated, a set of cytokine signaling pathways coupled with activation of lineage-specific transcription factors and epigenetic modifications at appropriate genes are required. The effector functions of these cells are mediated by the cytokines secreted by the differentiated cells. This paper will focus on the cytokine-signaling and the network of transcription factors responsible for the differentiation of naive CD4+T cells. |
| format | Article |
| id | doaj-art-7dfdfd1fb38944f4b3fc177e7aedc762 |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-7dfdfd1fb38944f4b3fc177e7aedc7622025-08-20T02:09:05ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/925135925135CD4+T Cells: Differentiation and FunctionsRishi Vishal Luckheeram0Rui Zhou1Asha Devi Verma2Bing Xia3Department of Gastroenterology, Zhongnan Hospital, Wuhan University School of Medicine, Wuhan 430071, ChinaDepartment of Gastroenterology, Zhongnan Hospital, Wuhan University School of Medicine, Wuhan 430071, ChinaDepartment of Paediatrics, Renmin Hospital, Wuhan University School of Medicine, Wuhan 430071, ChinaDepartment of Gastroenterology, Zhongnan Hospital, Wuhan University School of Medicine, Wuhan 430071, ChinaCD4+T cells are crucial in achieving a regulated effective immune response to pathogens. Naive CD4+T cells are activated after interaction with antigen-MHC complex and differentiate into specific subtypes depending mainly on the cytokine milieu of the microenvironment. Besides the classical T-helper 1 and T-helper 2, other subsets have been identified, including T-helper 17, regulatory T cell, follicular helper T cell, and T-helper 9, each with a characteristic cytokine profile. For a particular phenotype to be differentiated, a set of cytokine signaling pathways coupled with activation of lineage-specific transcription factors and epigenetic modifications at appropriate genes are required. The effector functions of these cells are mediated by the cytokines secreted by the differentiated cells. This paper will focus on the cytokine-signaling and the network of transcription factors responsible for the differentiation of naive CD4+T cells.http://dx.doi.org/10.1155/2012/925135 |
| spellingShingle | Rishi Vishal Luckheeram Rui Zhou Asha Devi Verma Bing Xia CD4+T Cells: Differentiation and Functions Clinical and Developmental Immunology |
| title | CD4+T Cells: Differentiation and Functions |
| title_full | CD4+T Cells: Differentiation and Functions |
| title_fullStr | CD4+T Cells: Differentiation and Functions |
| title_full_unstemmed | CD4+T Cells: Differentiation and Functions |
| title_short | CD4+T Cells: Differentiation and Functions |
| title_sort | cd4 t cells differentiation and functions |
| url | http://dx.doi.org/10.1155/2012/925135 |
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