Modulation of muscle anabolism and gut microbiota by Polyporus umbellatus extract attenuates dexamethasone-induced muscle atrophy

Modulation of muscle anabolism and gut microbiota by Polyporus umbellatus extract attenuates dexamethasone-induced muscle atrophy

Abstract To investigate the pharmacological mechanisms by extract of Polyporus umbellatus (PU) protects against dexamethasone (DEX)-induced muscle atrophy, focusing on its direct effects on muscle cell signaling, mitochondrial function, oxidative stress, and its indirect influence via gut microbiota...

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Main Authors: Nguyen Bao Ngoc, Subeen Kim, Hye-Young Youn, Huitae Min, Tam Thi Le, Mauliasari Intan Rizki, Dae Won Kim, Kwang Hyeon Cha, Young Tae Park, Sang Hoon Jung, Myungsuk Kim
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:Applied Biological Chemistry
Subjects:
Polyporus umbellatus
Muscle atrophy
Dexamethasone
Mitochondrial biogenesis
Gut microbiota
Lactobacillus gasseri
Online Access:https://doi.org/10.1186/s13765-025-01014-9
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