The Gap to Fill: Rationale for Rapid Initiation and Optimal Titration of Comprehensive Disease-modifying Medical Therapy for Heart Failure with Reduced Ejection Fraction
There are gaps in the use of therapies that save lives and improve quality of life for patients with heart failure with reduced ejection fraction, both in the US and abroad. The evidence is clear that initiation and titration of guideline-directed medical therapy (GDMT) and comprehensive disease-mod...
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| Format: | Article |
| Language: | English |
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Radcliffe Medical Media
2021-11-01
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| Series: | Cardiac Failure Review |
| Online Access: | https://www.cfrjournal.com/articleindex/cfr.2021.18 |
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| author | Nicholas K Brownell Boback Ziaeian Gregg C Fonarow |
| author_facet | Nicholas K Brownell Boback Ziaeian Gregg C Fonarow |
| author_sort | Nicholas K Brownell |
| collection | DOAJ |
| description | There are gaps in the use of therapies that save lives and improve quality of life for patients with heart failure with reduced ejection fraction, both in the US and abroad. The evidence is clear that initiation and titration of guideline-directed medical therapy (GDMT) and comprehensive disease-modifying medical therapy (CDMMT) to maximally tolerated doses improves patient-focused outcomes, yet observational data suggest this does not happen. The purpose of this review is to describe the gap in the use of optimal treatment worldwide and discuss the benefits of newer heart failure therapies including angiotensin receptor-neprilysin inhibitors and sodium-glucose cotransporter 2 inhibitors. It will also cover the efficacy and safety of such treatments and provide potential pathways for the initiation and rapid titration of GDMT/CDMMT. |
| format | Article |
| id | doaj-art-7df8f12bd1b04596939dc345b61dda0f |
| institution | Kabale University |
| issn | 2057-7540 2057-7559 |
| language | English |
| publishDate | 2021-11-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | Cardiac Failure Review |
| spelling | doaj-art-7df8f12bd1b04596939dc345b61dda0f2024-12-14T16:03:10ZengRadcliffe Medical MediaCardiac Failure Review2057-75402057-75592021-11-01710.15420/cfr.2021.18The Gap to Fill: Rationale for Rapid Initiation and Optimal Titration of Comprehensive Disease-modifying Medical Therapy for Heart Failure with Reduced Ejection FractionNicholas K Brownell0Boback Ziaeian1Gregg C Fonarow2Division of Cardiology, University of California Los Angeles (UCLA), Los Angeles, CA, USDivision of Cardiology, University of California Los Angeles (UCLA), Los Angeles, CA, USDivision of Cardiology, University of California Los Angeles (UCLA), Los Angeles, CA, US; Ahmanson-UCLA Cardiomyopathy Center, Ronald Reagan-UCLA Medical Center, Los Angeles, CA, USThere are gaps in the use of therapies that save lives and improve quality of life for patients with heart failure with reduced ejection fraction, both in the US and abroad. The evidence is clear that initiation and titration of guideline-directed medical therapy (GDMT) and comprehensive disease-modifying medical therapy (CDMMT) to maximally tolerated doses improves patient-focused outcomes, yet observational data suggest this does not happen. The purpose of this review is to describe the gap in the use of optimal treatment worldwide and discuss the benefits of newer heart failure therapies including angiotensin receptor-neprilysin inhibitors and sodium-glucose cotransporter 2 inhibitors. It will also cover the efficacy and safety of such treatments and provide potential pathways for the initiation and rapid titration of GDMT/CDMMT.https://www.cfrjournal.com/articleindex/cfr.2021.18 |
| spellingShingle | Nicholas K Brownell Boback Ziaeian Gregg C Fonarow The Gap to Fill: Rationale for Rapid Initiation and Optimal Titration of Comprehensive Disease-modifying Medical Therapy for Heart Failure with Reduced Ejection Fraction Cardiac Failure Review |
| title | The Gap to Fill: Rationale for Rapid Initiation and Optimal Titration of Comprehensive Disease-modifying Medical Therapy for Heart Failure with Reduced Ejection Fraction |
| title_full | The Gap to Fill: Rationale for Rapid Initiation and Optimal Titration of Comprehensive Disease-modifying Medical Therapy for Heart Failure with Reduced Ejection Fraction |
| title_fullStr | The Gap to Fill: Rationale for Rapid Initiation and Optimal Titration of Comprehensive Disease-modifying Medical Therapy for Heart Failure with Reduced Ejection Fraction |
| title_full_unstemmed | The Gap to Fill: Rationale for Rapid Initiation and Optimal Titration of Comprehensive Disease-modifying Medical Therapy for Heart Failure with Reduced Ejection Fraction |
| title_short | The Gap to Fill: Rationale for Rapid Initiation and Optimal Titration of Comprehensive Disease-modifying Medical Therapy for Heart Failure with Reduced Ejection Fraction |
| title_sort | gap to fill rationale for rapid initiation and optimal titration of comprehensive disease modifying medical therapy for heart failure with reduced ejection fraction |
| url | https://www.cfrjournal.com/articleindex/cfr.2021.18 |
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