Treatment of Neuroendocrine Tumor Liver Metastases
In the care of patients with hepatic neuroendocrine metastases, medical oncologists should work in multidisciplinary fashion with surgeons, interventional radiologists, and radiation oncologists to assess the potential utility of liver-directed and systemic therapies. This paper addresses the variou...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2012/973946 |
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| _version_ | 1850213801628008448 |
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| author | Mark A. Lewis Timothy J. Hobday |
| author_facet | Mark A. Lewis Timothy J. Hobday |
| author_sort | Mark A. Lewis |
| collection | DOAJ |
| description | In the care of patients with hepatic neuroendocrine metastases, medical oncologists should work in multidisciplinary fashion with surgeons, interventional radiologists, and radiation oncologists to assess the potential utility of liver-directed and systemic therapies. This paper addresses the various roles and evidence basis for cytoreductive surgery, thermal ablation (radiofrequency, microwave, and cryoablation), and embolization (bland embolization (HAE), chemoembolization (HACE), and radioembolization) as liver-directed therapies. Somatostatin analogues, cytotoxic chemotherapy, and the newer agents everolimus and suntinib are discussed as a means for controlling intra- and extrahepatic disease, along with peptide receptor radiotherapy (PRRT). Finally, the experience with orthotopic liver transplant for neuroendocrine tumors is described. |
| format | Article |
| id | doaj-art-7df690273bb54b21bdf12366cff59e29 |
| institution | OA Journals |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-7df690273bb54b21bdf12366cff59e292025-08-20T02:09:04ZengWileyInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/973946973946Treatment of Neuroendocrine Tumor Liver MetastasesMark A. Lewis0Timothy J. Hobday1Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USADivision of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USAIn the care of patients with hepatic neuroendocrine metastases, medical oncologists should work in multidisciplinary fashion with surgeons, interventional radiologists, and radiation oncologists to assess the potential utility of liver-directed and systemic therapies. This paper addresses the various roles and evidence basis for cytoreductive surgery, thermal ablation (radiofrequency, microwave, and cryoablation), and embolization (bland embolization (HAE), chemoembolization (HACE), and radioembolization) as liver-directed therapies. Somatostatin analogues, cytotoxic chemotherapy, and the newer agents everolimus and suntinib are discussed as a means for controlling intra- and extrahepatic disease, along with peptide receptor radiotherapy (PRRT). Finally, the experience with orthotopic liver transplant for neuroendocrine tumors is described.http://dx.doi.org/10.1155/2012/973946 |
| spellingShingle | Mark A. Lewis Timothy J. Hobday Treatment of Neuroendocrine Tumor Liver Metastases International Journal of Hepatology |
| title | Treatment of Neuroendocrine Tumor Liver Metastases |
| title_full | Treatment of Neuroendocrine Tumor Liver Metastases |
| title_fullStr | Treatment of Neuroendocrine Tumor Liver Metastases |
| title_full_unstemmed | Treatment of Neuroendocrine Tumor Liver Metastases |
| title_short | Treatment of Neuroendocrine Tumor Liver Metastases |
| title_sort | treatment of neuroendocrine tumor liver metastases |
| url | http://dx.doi.org/10.1155/2012/973946 |
| work_keys_str_mv | AT markalewis treatmentofneuroendocrinetumorlivermetastases AT timothyjhobday treatmentofneuroendocrinetumorlivermetastases |