Regulatory T Cell Mimicry by a Subset of Mesenchymal GBM Stem Cells Suppresses CD4 and CD8 Cells

Regulatory T Cell Mimicry by a Subset of Mesenchymal GBM Stem Cells Suppresses CD4 and CD8 Cells

Attempts to activate an anti-tumor immune response in glioblastoma (GBM) have been met with many challenges due to its inherently immunosuppressive tumor microenvironment. The degree and mechanisms by which molecularly and phenotypically diverse tumor-propagating glioma stem cells (GSCs) contribute...

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Bibliographic Details
Main Authors: Amanda L. Johnson, Harmon S. Khela, Jack Korleski, Sophie Sall, Yunqing Li, Weiqiang Zhou, Karen Smith-Connor, John Laterra, Hernando Lopez-Bertoni
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Cells
Subjects:
TGFBR2
GBM
GSC
immunosuppression
Online Access:https://www.mdpi.com/2073-4409/14/8/592
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