CXCL12/CXCR4 axis mediates CD8 + T cell overactivation in the progression of viral myocarditis

CXCL12/CXCR4 axis mediates CD8 + T cell overactivation in the progression of viral myocarditis

Abstract Background Myocarditis is a common inflammatory heart disease in children and young adults, with fulminant myocarditis (FM) being the most severe form due to its rapid onset and high mortality rate. However, the precise pathological immune subsets and molecular change in myocarditis, partic...

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Bibliographic Details
Main Authors: Li Zhang, Keyu Liu, Xiuyun Duan, Shan Zhou, Hailin Jia, Yingnan You, Bo Han
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Translational Medicine
Subjects:
Myocarditis
Single-cell RNA sequencing
CXCR4
CD8+T cell
Online Access:https://doi.org/10.1186/s12967-025-06394-6
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