A clinical case of disseminated BCG infection with a fatal outcome

Complications after the introduction of the tuberculosis vaccine develop extremely rarely. They become accidentally vaccinated infants with undiagnosed severe immunodeficiency. The article considers a clinical case of the course of disseminated BCG infection with multiple organ damage in congenital...

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Bibliographic Details
Main Authors: S. M. Kharit, Yu. E. Konstantinova, V. E. Karev, I. A. Karabak, A. I. Konev, K. K. Tikhomirova, M. E. Lozovskaja
Format: Article
Language:Russian
Published: Journal Infectology 2024-04-01
Series:Журнал инфектологии
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Online Access:https://journal.niidi.ru/jofin/article/view/1618
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Summary:Complications after the introduction of the tuberculosis vaccine develop extremely rarely. They become accidentally vaccinated infants with undiagnosed severe immunodeficiency. The article considers a clinical case of the course of disseminated BCG infection with multiple organ damage in congenital immunodeficiency in a 9-month-old boy. The disease manifested itself acutely, the child’s condition worsened within a week, and its outcome was the death of the baby. Primary immunodeficiency was confirmed by the results of a pathoanatomic examination. The discussion provides a classification of complications after the introduction of BCG vaccine, the algorithm of the doctor’s actions in case of a suspected complication after vaccination, and also describes the main signs of immunodeficiency.
ISSN:2072-6732