The First K<sup>+</sup>-Channel Blocker Described from <i>Tityus fasciolatus</i> Venom: The Purification, Molecular Cloning, and Functional Characterization of α-KTx4.9 (Tf5)

The First K<sup>+</sup>-Channel Blocker Described from <i>Tityus fasciolatus</i> Venom: The Purification, Molecular Cloning, and Functional Characterization of α-KTx4.9 (Tf5)

Hundreds of toxins, particularly from scorpions of lesser medical significance, remain unknown, especially those from species endemic to specific ecosystems, such as <i>Tityus fasciolatus</i>. Their discovery could contribute to the development of new drugs for channelopathies and other...

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Bibliographic Details
Main Authors: Isolda de Sousa Monteiro, Israel Flor Silva de Araújo, Thalita Soares Camargos, Ernesto Ortiz, Adolfo Carlos Barros de Souza, Jonathan Dias Lima, Lourival D. Possani, Elisabeth Ferroni Schwartz, Diogo Vieira Tibery
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Toxins
Subjects:
KTxs
K<sup>+</sup>-channel
scorpion
Kv1.2
Kv1.3
Tf5
Online Access:https://www.mdpi.com/2072-6651/17/2/96
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