A high throughput, high content screen for non-toxic small molecules that reduce levels of the nuclear lamina protein, Lamin B1

A high throughput, high content screen for non-toxic small molecules that reduce levels of the nuclear lamina protein, Lamin B1

Abstract Lamin B1 (LMNB1) is an intermediate filament protein that is an integral component of the nuclear lamina, a structure that is critical for nuclear organization and function. Mutations involving the lamin B1 gene cause the adult-onset demyelinating disorder, Autosomal Dominant Leukodystrophy...

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Bibliographic Details
Main Authors: Laura L. Vollmer, Fang Liu, Bruce Nmezi, Guillermo Rodriguez Bey, Nathan Herdman, Tong Ying Shun, Albert Gough, Ruiting Liu, Peter Wipf, Timothy R. Lezon, Quasar S. Padiath, Andreas Vogt
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Lamin B1
Laminopathies
Autosomal dominant leukodystrophy
High-content screening
Online Access:https://doi.org/10.1038/s41598-025-91546-3
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