Case Report: Reversible chorea arising from severe vitamin B12 deficiency due to autoimmune gastritis: a comprehensive case study

Cognitive impairment, ocular neuropathy, sensorimotor polyneuropathy, and subacute combined spinal cord degeneration can all result from a common illness called vitamin B12 insufficiency. With regard to extrapyramidal movement disorders, it is rare, frequently misdiagnosed, and under recognized, whi...

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Main Authors: Meifang Yang, Yifan Geng, Zhiren Chen, Zixuan Zhou, Wenjuan Huang, Weiwei Chen, Xia Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Nutrition
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Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2025.1590837/full
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author Meifang Yang
Meifang Yang
Meifang Yang
Yifan Geng
Yifan Geng
Yifan Geng
Zhiren Chen
Zixuan Zhou
Zixuan Zhou
Zixuan Zhou
Wenjuan Huang
Wenjuan Huang
Weiwei Chen
Weiwei Chen
Xia Zhang
Xia Zhang
author_facet Meifang Yang
Meifang Yang
Meifang Yang
Yifan Geng
Yifan Geng
Yifan Geng
Zhiren Chen
Zixuan Zhou
Zixuan Zhou
Zixuan Zhou
Wenjuan Huang
Wenjuan Huang
Weiwei Chen
Weiwei Chen
Xia Zhang
Xia Zhang
author_sort Meifang Yang
collection DOAJ
description Cognitive impairment, ocular neuropathy, sensorimotor polyneuropathy, and subacute combined spinal cord degeneration can all result from a common illness called vitamin B12 insufficiency. With regard to extrapyramidal movement disorders, it is rare, frequently misdiagnosed, and under recognized, which postpones timely treatment. A case study of a 66-year-old man with acute-onset and reversible choreoathetoid symptoms is presented in this publication. A significant vitamin B12 deficiency and an abnormal hypermetabolism in the basal ganglia region were detected by 18F-FDG PET/CT. Remarkably, the patient’s dyskinesia disappeared as soon as vitamin B12 replacement therapy was administered. The patient’s etiology was identified as a mix of vitamin B12 malabsorption and inadequate intake from autoimmune-related gastritis. In order to achieve the best potential therapeutic results, this case highlights the importance of timely and correct diagnosis, timely treatment of vitamin B12 deficiency based on its underlying etiology, and careful research of multiple etiologies.
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institution Kabale University
issn 2296-861X
language English
publishDate 2025-08-01
publisher Frontiers Media S.A.
record_format Article
series Frontiers in Nutrition
spelling doaj-art-7de71d2bf10b4c839b407e87dd4c89772025-08-21T04:10:29ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-08-011210.3389/fnut.2025.15908371590837Case Report: Reversible chorea arising from severe vitamin B12 deficiency due to autoimmune gastritis: a comprehensive case studyMeifang Yang0Meifang Yang1Meifang Yang2Yifan Geng3Yifan Geng4Yifan Geng5Zhiren Chen6Zixuan Zhou7Zixuan Zhou8Zixuan Zhou9Wenjuan Huang10Wenjuan Huang11Weiwei Chen12Weiwei Chen13Xia Zhang14Xia Zhang15Department of Neurology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou School of Clinical Medicine of Nanjing Medical University, Xuzhou, Jiangsu, ChinaSoutheast University Affiliated Xuzhou Central Hospital, Xuzhou, Jiangsu, ChinaDepartment of Neurology, Xuzhou Clinical College, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of Neurology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou School of Clinical Medicine of Nanjing Medical University, Xuzhou, Jiangsu, ChinaSoutheast University Affiliated Xuzhou Central Hospital, Xuzhou, Jiangsu, ChinaDepartment of Neurology, Xuzhou Clinical College, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of Neurology, Xuzhou Clinical College, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of Neurology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou School of Clinical Medicine of Nanjing Medical University, Xuzhou, Jiangsu, ChinaSoutheast University Affiliated Xuzhou Central Hospital, Xuzhou, Jiangsu, ChinaDepartment of Neurology, Xuzhou Clinical College, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of Neurology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou School of Clinical Medicine of Nanjing Medical University, Xuzhou, Jiangsu, ChinaSoutheast University Affiliated Xuzhou Central Hospital, Xuzhou, Jiangsu, ChinaDepartment of Neurology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou School of Clinical Medicine of Nanjing Medical University, Xuzhou, Jiangsu, ChinaSoutheast University Affiliated Xuzhou Central Hospital, Xuzhou, Jiangsu, ChinaDepartment of Neurology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou School of Clinical Medicine of Nanjing Medical University, Xuzhou, Jiangsu, ChinaSoutheast University Affiliated Xuzhou Central Hospital, Xuzhou, Jiangsu, ChinaCognitive impairment, ocular neuropathy, sensorimotor polyneuropathy, and subacute combined spinal cord degeneration can all result from a common illness called vitamin B12 insufficiency. With regard to extrapyramidal movement disorders, it is rare, frequently misdiagnosed, and under recognized, which postpones timely treatment. A case study of a 66-year-old man with acute-onset and reversible choreoathetoid symptoms is presented in this publication. A significant vitamin B12 deficiency and an abnormal hypermetabolism in the basal ganglia region were detected by 18F-FDG PET/CT. Remarkably, the patient’s dyskinesia disappeared as soon as vitamin B12 replacement therapy was administered. The patient’s etiology was identified as a mix of vitamin B12 malabsorption and inadequate intake from autoimmune-related gastritis. In order to achieve the best potential therapeutic results, this case highlights the importance of timely and correct diagnosis, timely treatment of vitamin B12 deficiency based on its underlying etiology, and careful research of multiple etiologies.https://www.frontiersin.org/articles/10.3389/fnut.2025.1590837/fullvitamin B12 deficiencychoreaautoimmune gastritis18F-FDG PET/CTmovement disorders
spellingShingle Meifang Yang
Meifang Yang
Meifang Yang
Yifan Geng
Yifan Geng
Yifan Geng
Zhiren Chen
Zixuan Zhou
Zixuan Zhou
Zixuan Zhou
Wenjuan Huang
Wenjuan Huang
Weiwei Chen
Weiwei Chen
Xia Zhang
Xia Zhang
Case Report: Reversible chorea arising from severe vitamin B12 deficiency due to autoimmune gastritis: a comprehensive case study
Frontiers in Nutrition
vitamin B12 deficiency
chorea
autoimmune gastritis
18F-FDG PET/CT
movement disorders
title Case Report: Reversible chorea arising from severe vitamin B12 deficiency due to autoimmune gastritis: a comprehensive case study
title_full Case Report: Reversible chorea arising from severe vitamin B12 deficiency due to autoimmune gastritis: a comprehensive case study
title_fullStr Case Report: Reversible chorea arising from severe vitamin B12 deficiency due to autoimmune gastritis: a comprehensive case study
title_full_unstemmed Case Report: Reversible chorea arising from severe vitamin B12 deficiency due to autoimmune gastritis: a comprehensive case study
title_short Case Report: Reversible chorea arising from severe vitamin B12 deficiency due to autoimmune gastritis: a comprehensive case study
title_sort case report reversible chorea arising from severe vitamin b12 deficiency due to autoimmune gastritis a comprehensive case study
topic vitamin B12 deficiency
chorea
autoimmune gastritis
18F-FDG PET/CT
movement disorders
url https://www.frontiersin.org/articles/10.3389/fnut.2025.1590837/full
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