dCas9-HDAC8-EGFP fusion enables epigenetic editing of breast cancer cells by H3K9 deacetylation

dCas9-HDAC8-EGFP fusion enables epigenetic editing of breast cancer cells by H3K9 deacetylation

Epigenetic editing is thriving as a robust tool for manipulating transcriptional regulation and cell fate. Despite its regulatory role in gene downregulation, epigenetic editing with histone deacetylation has been sparsely studied, especially in the context of cancer. In this current study, we have...

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Bibliographic Details
Main Authors:	Mohammad Mijanur Rahman, Trygve O. Tollefsbol
Format:	Article
Language:	English
Published:	Elsevier 2024-12-01
Series:	European Journal of Cell Biology
Subjects:	Epigenetic editing Histone deacetylation DCas9-HDAC8-EGFP HDAC inhibitor
Online Access:	http://www.sciencedirect.com/science/article/pii/S0171933524000803
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