Simplex lattice design for optimization of the mass ratio of Curcuma longa L., Curcuma zedoaria (Christm.) Roscoe and Curcuma aromatica Salisb. to maximize curcuminoids content and antioxidant activity
The aim of this work was to optimize the mass ratio of three Curcuma plants’ rhizomes to obtain the highest curcuminoid content and antioxidant activity using the simplex lattice design. The selected Curcuma plants were C. longa, C. zedoaria and C. aromatica. The simplex lattice design was applied i...
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| Language: | English |
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Sciendo
2021-09-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2021-0025 |
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| author | Monton Chaowalit Chuanchom Panupong Popanit Puwadon Settharaksa Sukanya Pathompak Pathamaporn |
| author_facet | Monton Chaowalit Chuanchom Panupong Popanit Puwadon Settharaksa Sukanya Pathompak Pathamaporn |
| author_sort | Monton Chaowalit |
| collection | DOAJ |
| description | The aim of this work was to optimize the mass ratio of three Curcuma plants’ rhizomes to obtain the highest curcuminoid content and antioxidant activity using the simplex lattice design. The selected Curcuma plants were C. longa, C. zedoaria and C. aromatica. The simplex lattice design was applied in the work. The individual curcuminoids (curcumin, demethoxycurcumin and bis-demethoxycurcumin) and total curcuminoid content were determined using high-performance liquid chromatography. Curcuma longa alone provided the highest content of bis-demethoxycurcumin and demethoxycurcumin. A mixture of C. longa and C. aromatica in the mass ratio of 72:28 % provided the highest curcumin content. The results showed that C. longa alone exhibited the highest antioxidant activity. |
| format | Article |
| id | doaj-art-7de3ab026c974ec88941929ab1eded2c |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2021-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-7de3ab026c974ec88941929ab1eded2c2025-02-02T17:46:44ZengSciendoActa Pharmaceutica1846-95582021-09-0171344545710.2478/acph-2021-0025acph-2021-0025Simplex lattice design for optimization of the mass ratio of Curcuma longa L., Curcuma zedoaria (Christm.) Roscoe and Curcuma aromatica Salisb. to maximize curcuminoids content and antioxidant activityMonton Chaowalit0Chuanchom Panupong1Popanit Puwadon2Settharaksa Sukanya3Pathompak Pathamaporn4Drug and Herbal Product Research and Development Center, College of Pharmacy, Rangsit University, Pathum Thani 12000, ThailandDrug and Herbal Product Research and Development Center, College of Pharmacy, Rangsit University, Pathum Thani 12000, ThailandDrug and Herbal Product Research and Development Center, College of Pharmacy, Rangsit University, Pathum Thani 12000, ThailandDrug and Herbal Product Research and Development Center, College of Pharmacy, Rangsit University, Pathum Thani 12000, ThailandDrug and Herbal Product Research and Development Center, College of Pharmacy, Rangsit University, Pathum Thani 12000, ThailandThe aim of this work was to optimize the mass ratio of three Curcuma plants’ rhizomes to obtain the highest curcuminoid content and antioxidant activity using the simplex lattice design. The selected Curcuma plants were C. longa, C. zedoaria and C. aromatica. The simplex lattice design was applied in the work. The individual curcuminoids (curcumin, demethoxycurcumin and bis-demethoxycurcumin) and total curcuminoid content were determined using high-performance liquid chromatography. Curcuma longa alone provided the highest content of bis-demethoxycurcumin and demethoxycurcumin. A mixture of C. longa and C. aromatica in the mass ratio of 72:28 % provided the highest curcumin content. The results showed that C. longa alone exhibited the highest antioxidant activity.https://doi.org/10.2478/acph-2021-0025curcumacurcuminoidshplcsimplex lattice designoptimizationantioxidant activity |
| spellingShingle | Monton Chaowalit Chuanchom Panupong Popanit Puwadon Settharaksa Sukanya Pathompak Pathamaporn Simplex lattice design for optimization of the mass ratio of Curcuma longa L., Curcuma zedoaria (Christm.) Roscoe and Curcuma aromatica Salisb. to maximize curcuminoids content and antioxidant activity Acta Pharmaceutica curcuma curcuminoids hplc simplex lattice design optimization antioxidant activity |
| title | Simplex lattice design for optimization of the mass ratio of Curcuma longa L., Curcuma zedoaria (Christm.) Roscoe and Curcuma aromatica Salisb. to maximize curcuminoids content and antioxidant activity |
| title_full | Simplex lattice design for optimization of the mass ratio of Curcuma longa L., Curcuma zedoaria (Christm.) Roscoe and Curcuma aromatica Salisb. to maximize curcuminoids content and antioxidant activity |
| title_fullStr | Simplex lattice design for optimization of the mass ratio of Curcuma longa L., Curcuma zedoaria (Christm.) Roscoe and Curcuma aromatica Salisb. to maximize curcuminoids content and antioxidant activity |
| title_full_unstemmed | Simplex lattice design for optimization of the mass ratio of Curcuma longa L., Curcuma zedoaria (Christm.) Roscoe and Curcuma aromatica Salisb. to maximize curcuminoids content and antioxidant activity |
| title_short | Simplex lattice design for optimization of the mass ratio of Curcuma longa L., Curcuma zedoaria (Christm.) Roscoe and Curcuma aromatica Salisb. to maximize curcuminoids content and antioxidant activity |
| title_sort | simplex lattice design for optimization of the mass ratio of curcuma longa l curcuma zedoaria christm roscoe and curcuma aromatica salisb to maximize curcuminoids content and antioxidant activity |
| topic | curcuma curcuminoids hplc simplex lattice design optimization antioxidant activity |
| url | https://doi.org/10.2478/acph-2021-0025 |
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