Cytotoxic Chemotherapy and CD4+ Effector T Cells: An Emerging Alliance for Durable Antitumor Effects
Standard cytotoxic chemotherapy can initially achieve high response rates, but relapses often occur in patients and represent a severe clinical problem. As increasing numbers of chemotherapeutic agents are found to have immunostimulatory effects, there is a growing interest to combine chemotherapy a...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/890178 |
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| _version_ | 1849409809230594048 |
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| author | Zhi-Chun Ding Gang Zhou |
| author_facet | Zhi-Chun Ding Gang Zhou |
| author_sort | Zhi-Chun Ding |
| collection | DOAJ |
| description | Standard cytotoxic chemotherapy can initially achieve high response rates, but relapses often occur in patients and represent a severe clinical problem. As increasing numbers of chemotherapeutic agents are found to have immunostimulatory effects, there is a growing interest to combine chemotherapy and immunotherapy for synergistic antitumor effects and improved clinical benefits. Findings from recent studies suggest that highly activated, polyfunctional CD4+ effector T cells have tremendous potential in strengthening and sustaining the overall host antitumor immunity in the postchemotherapy window. This review focuses on the latest progresses regarding the impact of chemotherapy on CD4+ T-cell phenotype and function and discusses the prospect of exploiting CD4+ T cells to control tumor progression and prevent relapse after chemotherapy. |
| format | Article |
| id | doaj-art-7ddfab3fe3d64e9f85a81e6223e78fbe |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-7ddfab3fe3d64e9f85a81e6223e78fbe2025-08-20T03:35:23ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/890178890178Cytotoxic Chemotherapy and CD4+ Effector T Cells: An Emerging Alliance for Durable Antitumor EffectsZhi-Chun Ding0Gang Zhou1Cancer Immunotherapy Program, Cancer Center, Georgia Health Sciences University, Augusta, GA 30912, USACancer Immunotherapy Program, Cancer Center, Georgia Health Sciences University, Augusta, GA 30912, USAStandard cytotoxic chemotherapy can initially achieve high response rates, but relapses often occur in patients and represent a severe clinical problem. As increasing numbers of chemotherapeutic agents are found to have immunostimulatory effects, there is a growing interest to combine chemotherapy and immunotherapy for synergistic antitumor effects and improved clinical benefits. Findings from recent studies suggest that highly activated, polyfunctional CD4+ effector T cells have tremendous potential in strengthening and sustaining the overall host antitumor immunity in the postchemotherapy window. This review focuses on the latest progresses regarding the impact of chemotherapy on CD4+ T-cell phenotype and function and discusses the prospect of exploiting CD4+ T cells to control tumor progression and prevent relapse after chemotherapy.http://dx.doi.org/10.1155/2012/890178 |
| spellingShingle | Zhi-Chun Ding Gang Zhou Cytotoxic Chemotherapy and CD4+ Effector T Cells: An Emerging Alliance for Durable Antitumor Effects Clinical and Developmental Immunology |
| title | Cytotoxic Chemotherapy and CD4+ Effector T Cells: An Emerging Alliance for Durable Antitumor Effects |
| title_full | Cytotoxic Chemotherapy and CD4+ Effector T Cells: An Emerging Alliance for Durable Antitumor Effects |
| title_fullStr | Cytotoxic Chemotherapy and CD4+ Effector T Cells: An Emerging Alliance for Durable Antitumor Effects |
| title_full_unstemmed | Cytotoxic Chemotherapy and CD4+ Effector T Cells: An Emerging Alliance for Durable Antitumor Effects |
| title_short | Cytotoxic Chemotherapy and CD4+ Effector T Cells: An Emerging Alliance for Durable Antitumor Effects |
| title_sort | cytotoxic chemotherapy and cd4 effector t cells an emerging alliance for durable antitumor effects |
| url | http://dx.doi.org/10.1155/2012/890178 |
| work_keys_str_mv | AT zhichunding cytotoxicchemotherapyandcd4effectortcellsanemergingalliancefordurableantitumoreffects AT gangzhou cytotoxicchemotherapyandcd4effectortcellsanemergingalliancefordurableantitumoreffects |