Aggressive recurrent intestinal-type adenocarcinoma of the nasal cavity: a case report and literature review
Intestinal-type adenocarcinoma (ITAC) of the nasal cavity is a rare, aggressive tumor that presents unique therapeutic challenges, particularly in cases of recurrent disease with intracranial extension. We present the case of a 54-year-old male with recurrent ITAC who demonstrated a remarkable respo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1510225/full |
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| author | YaoYao Chen Jiawei Xu Chengdong Yu Haoyu Shi Ling Luo Dingbang Peng Xiaofang Zhang Wen Chen Fei Le Fei Le |
| author_facet | YaoYao Chen Jiawei Xu Chengdong Yu Haoyu Shi Ling Luo Dingbang Peng Xiaofang Zhang Wen Chen Fei Le Fei Le |
| author_sort | YaoYao Chen |
| collection | DOAJ |
| description | Intestinal-type adenocarcinoma (ITAC) of the nasal cavity is a rare, aggressive tumor that presents unique therapeutic challenges, particularly in cases of recurrent disease with intracranial extension. We present the case of a 54-year-old male with recurrent ITAC who demonstrated a remarkable response to a novel triple-therapy approach. This patient lacked the typical risk factors, such as occupational exposure to wood or leather dust, making this case particularly unusual. After failing conventional treatments and experiencing multiple recurrences with progressive intracranial invasion, the patient received an innovative combination of immunotherapy (Toripalimab), targeted therapy (Anlotinib), and chemotherapy (S-1). This unprecedented therapeutic combination resulted in significant tumor volume reduction (from 53.9 × 42.7 mm to 38.9 × 18.8 mm) and marked improvement in neurological symptoms, particularly diplopia. To our knowledge, this represents the first case report of successful implementation of this specific triple therapy regimen for recurrent ITAC with intracranial extension. |
| format | Article |
| id | doaj-art-7dddcc7ed0e241d6a15ea459c80b6056 |
| institution | OA Journals |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-7dddcc7ed0e241d6a15ea459c80b60562025-08-20T02:12:19ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-04-011210.3389/fmed.2025.15102251510225Aggressive recurrent intestinal-type adenocarcinoma of the nasal cavity: a case report and literature reviewYaoYao Chen0Jiawei Xu1Chengdong Yu2Haoyu Shi3Ling Luo4Dingbang Peng5Xiaofang Zhang6Wen Chen7Fei Le8Fei Le9Jiangxi Medical College, Nanchang University, Nanchang, ChinaJiangxi Medical College, Nanchang University, Nanchang, ChinaJiangxi Medical College, Nanchang University, Nanchang, ChinaJiangxi Medical College, Nanchang University, Nanchang, ChinaJiangxi Medical College, Nanchang University, Nanchang, ChinaJiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of Pathology, Jiangxi Cancer Hospital, The Second Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Breast Surgery, Jiangxi Cancer Hospital, The Second Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaJiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of Head and Neck Surgery, Jiangxi Cancer Hospital, The Second Affiliated Hospital of Nanchang Medical College, Jiangxi Clinical Research Center for Cancer, Nanchang, ChinaIntestinal-type adenocarcinoma (ITAC) of the nasal cavity is a rare, aggressive tumor that presents unique therapeutic challenges, particularly in cases of recurrent disease with intracranial extension. We present the case of a 54-year-old male with recurrent ITAC who demonstrated a remarkable response to a novel triple-therapy approach. This patient lacked the typical risk factors, such as occupational exposure to wood or leather dust, making this case particularly unusual. After failing conventional treatments and experiencing multiple recurrences with progressive intracranial invasion, the patient received an innovative combination of immunotherapy (Toripalimab), targeted therapy (Anlotinib), and chemotherapy (S-1). This unprecedented therapeutic combination resulted in significant tumor volume reduction (from 53.9 × 42.7 mm to 38.9 × 18.8 mm) and marked improvement in neurological symptoms, particularly diplopia. To our knowledge, this represents the first case report of successful implementation of this specific triple therapy regimen for recurrent ITAC with intracranial extension.https://www.frontiersin.org/articles/10.3389/fmed.2025.1510225/fullintestinal-type adenocarcinomanasal cavityimmunotherapytargeted therapyrecurrencecase report |
| spellingShingle | YaoYao Chen Jiawei Xu Chengdong Yu Haoyu Shi Ling Luo Dingbang Peng Xiaofang Zhang Wen Chen Fei Le Fei Le Aggressive recurrent intestinal-type adenocarcinoma of the nasal cavity: a case report and literature review Frontiers in Medicine intestinal-type adenocarcinoma nasal cavity immunotherapy targeted therapy recurrence case report |
| title | Aggressive recurrent intestinal-type adenocarcinoma of the nasal cavity: a case report and literature review |
| title_full | Aggressive recurrent intestinal-type adenocarcinoma of the nasal cavity: a case report and literature review |
| title_fullStr | Aggressive recurrent intestinal-type adenocarcinoma of the nasal cavity: a case report and literature review |
| title_full_unstemmed | Aggressive recurrent intestinal-type adenocarcinoma of the nasal cavity: a case report and literature review |
| title_short | Aggressive recurrent intestinal-type adenocarcinoma of the nasal cavity: a case report and literature review |
| title_sort | aggressive recurrent intestinal type adenocarcinoma of the nasal cavity a case report and literature review |
| topic | intestinal-type adenocarcinoma nasal cavity immunotherapy targeted therapy recurrence case report |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1510225/full |
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