LC8 enhances 53BP1 foci through heterogeneous bridging of 53BP1 oligomers

LC8 enhances 53BP1 foci through heterogeneous bridging of 53BP1 oligomers

53BP1 is a key player in DNA repair and together with BRCA1 regulate selection of DNA double-strand break repair mechanisms. Localization of DNA repair factors to sites of DNA damage by 53BP1 is controlled by its oligomerization domain (OD) and binding to LC8, a hub protein that functions to dimeriz...

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Bibliographic Details
Main Authors: Jesse Howe, Douglas Walker, Kyle Tengler, Maya Sonpatki, Patrick N Reardon, Justin WC Leung, Elisar J Barbar
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
53BP1
oligomerization
multivalency
LC8
heterogeneity
isothermal titration calorimetry
Online Access:https://elifesciences.org/articles/102179
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