Influence of cyclodextrins on the photostability of selected drug molecules in solution and the solid-state
The photostability of selected drug molecules, including furosemide, prochlorperazine, diclofenac, piroxicam, midazolam and nifedipine was studied, the kinetics of photodegradation, identification of the photodegradants investigated and mechanisms of photodegradation proposed. Selected cyclodextrins...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2001-01-01
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| Series: | International Journal of Photoenergy |
| Online Access: | http://dx.doi.org/10.1155/S1110662X01000277 |
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| author | B. D. Glass M. E. Brown S. Daya M. S. Worthington P. Drummond E. Antunes M. Lebete S. Anoopkumar-Dukie D. Maharaj |
| author_facet | B. D. Glass M. E. Brown S. Daya M. S. Worthington P. Drummond E. Antunes M. Lebete S. Anoopkumar-Dukie D. Maharaj |
| author_sort | B. D. Glass |
| collection | DOAJ |
| description | The photostability of selected drug molecules, including furosemide, prochlorperazine, diclofenac,
piroxicam, midazolam and nifedipine was studied, the kinetics of photodegradation, identification
of the photodegradants investigated and mechanisms of photodegradation proposed. Selected cyclodextrins
altered the photodegradation profiles of diclofenac, piroxicam, midazolam and nifedipine by either accelerating
or retarding the rate of photodegradation and generating novel photodegradants. |
| format | Article |
| id | doaj-art-7dcffd9c62ab4e44938c2e30ae560aec |
| institution | Kabale University |
| issn | 1110-662X |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Photoenergy |
| spelling | doaj-art-7dcffd9c62ab4e44938c2e30ae560aec2025-02-03T01:01:50ZengWileyInternational Journal of Photoenergy1110-662X2001-01-013420521110.1155/S1110662X01000277Influence of cyclodextrins on the photostability of selected drug molecules in solution and the solid-stateB. D. Glass0M. E. Brown1S. Daya2M. S. Worthington3P. Drummond4E. Antunes5M. Lebete6S. Anoopkumar-Dukie7D. Maharaj8Faculty of Pharmacy, Rhodes University, PO Box 94, Grahamstown 6140, South AfricaDepartment of Chemistry, Rhodes University, PO Box 94, Grahamstown 6140, South AfricaFaculty of Pharmacy, Rhodes University, PO Box 94, Grahamstown 6140, South AfricaAspen-Pharmacare, PO Box 4002, Korsten 6014, South AfricaFaculty of Pharmacy, Rhodes University, PO Box 94, Grahamstown 6140, South AfricaDepartment of Chemistry, Rhodes University, PO Box 94, Grahamstown 6140, South AfricaFaculty of Pharmacy, Rhodes University, PO Box 94, Grahamstown 6140, South AfricaFaculty of Pharmacy, Rhodes University, PO Box 94, Grahamstown 6140, South AfricaFaculty of Pharmacy, Rhodes University, PO Box 94, Grahamstown 6140, South AfricaThe photostability of selected drug molecules, including furosemide, prochlorperazine, diclofenac, piroxicam, midazolam and nifedipine was studied, the kinetics of photodegradation, identification of the photodegradants investigated and mechanisms of photodegradation proposed. Selected cyclodextrins altered the photodegradation profiles of diclofenac, piroxicam, midazolam and nifedipine by either accelerating or retarding the rate of photodegradation and generating novel photodegradants.http://dx.doi.org/10.1155/S1110662X01000277 |
| spellingShingle | B. D. Glass M. E. Brown S. Daya M. S. Worthington P. Drummond E. Antunes M. Lebete S. Anoopkumar-Dukie D. Maharaj Influence of cyclodextrins on the photostability of selected drug molecules in solution and the solid-state International Journal of Photoenergy |
| title | Influence of cyclodextrins on the photostability of selected drug molecules in solution and the solid-state |
| title_full | Influence of cyclodextrins on the photostability of selected drug molecules in solution and the solid-state |
| title_fullStr | Influence of cyclodextrins on the photostability of selected drug molecules in solution and the solid-state |
| title_full_unstemmed | Influence of cyclodextrins on the photostability of selected drug molecules in solution and the solid-state |
| title_short | Influence of cyclodextrins on the photostability of selected drug molecules in solution and the solid-state |
| title_sort | influence of cyclodextrins on the photostability of selected drug molecules in solution and the solid state |
| url | http://dx.doi.org/10.1155/S1110662X01000277 |
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