Dynamic single-cell transcriptomic reveals the cellular heterogeneity and a novel fibroblast subpopulation in laryngotracheal stenosis

Abstract Background Laryngotracheal stenosis (LTS), a pathological narrowing of the upper airway caused by excessive extracellular matrix (ECM) deposition, often leads to dyspnea and even respiratory failure. However, systematic studies addressing the specific subpopulations and their contribution t...

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Bibliographic Details
Main Authors: Ziwei Liao, Yangyang Zheng, Mingjun Zhang, Xiaoyan Li, Jing Wang, Hongming Xu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Biology Direct
Subjects:
Online Access:https://doi.org/10.1186/s13062-025-00639-6
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