Effect of Herbal Syrup Linkus on Acute and Gross Toxicity and Electrolytes in Blood and Organs
Objective: To evaluate the effect of herbal syrup Linkus on acute and gross toxicity and electrolytes level in blood and organs. Materials and Methods: This interventional study was carried out in the department of Pharmacology, Faculty of Pharmacy,University of Karachi after approval from BASR-KU....
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| Format: | Article |
| Language: | English |
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Bahria Univerisy Health Sciences, Campus Karachi
2016-09-01
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| Series: | Journal of Bahria University Medical and Dental College |
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| Online Access: | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/205 |
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| author | Riffat Farooqui Rafeeq Alam Khan Tahira Zamir Nasim Karim |
| author_facet | Riffat Farooqui Rafeeq Alam Khan Tahira Zamir Nasim Karim |
| author_sort | Riffat Farooqui |
| collection | DOAJ |
| description |
Objective: To evaluate the effect of herbal syrup Linkus on acute and gross toxicity and electrolytes level in blood and organs.
Materials and Methods: This interventional study was carried out in the department of Pharmacology, Faculty of
Pharmacy,University of Karachi after approval from BASR-KU. In this study twenty-eight healthy rabbits of either sex weighing
0.90 kg to 1.2 kg. All animals were equally divided into four groups, one served as control group while, remaining three groups
received herbal syrup Linkus at three different doses. Acute toxicity was tested in mice by Lorke’s method whereas effect on
gross toxicity, blood and organ electrolytes was evaluated in Rabbits.
Results: Herbal syrup Linkus exhibited LD50 values greater than 5 gm / kg per 24 hrs. No gross toxicity and mortality was
observed during the whole experimental period. Non significant changes were observed in blood and organ electrolytes (Calcium,
Potassium and Sodium) level.
Conclusion: Herbal syrup Linkus has produced no toxic effect at the administered doses neither showed any significant change
in the electrolytes level in the blood and vital organs.
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| format | Article |
| id | doaj-art-7dc66c9ceacd4766aa4662441b55b51f |
| institution | DOAJ |
| issn | 2220-7562 2617-9482 |
| language | English |
| publishDate | 2016-09-01 |
| publisher | Bahria Univerisy Health Sciences, Campus Karachi |
| record_format | Article |
| series | Journal of Bahria University Medical and Dental College |
| spelling | doaj-art-7dc66c9ceacd4766aa4662441b55b51f2025-08-20T02:45:02ZengBahria Univerisy Health Sciences, Campus KarachiJournal of Bahria University Medical and Dental College2220-75622617-94822016-09-0164Effect of Herbal Syrup Linkus on Acute and Gross Toxicity and Electrolytes in Blood and OrgansRiffat FarooquiRafeeq Alam KhanTahira ZamirNasim Karim Objective: To evaluate the effect of herbal syrup Linkus on acute and gross toxicity and electrolytes level in blood and organs. Materials and Methods: This interventional study was carried out in the department of Pharmacology, Faculty of Pharmacy,University of Karachi after approval from BASR-KU. In this study twenty-eight healthy rabbits of either sex weighing 0.90 kg to 1.2 kg. All animals were equally divided into four groups, one served as control group while, remaining three groups received herbal syrup Linkus at three different doses. Acute toxicity was tested in mice by Lorke’s method whereas effect on gross toxicity, blood and organ electrolytes was evaluated in Rabbits. Results: Herbal syrup Linkus exhibited LD50 values greater than 5 gm / kg per 24 hrs. No gross toxicity and mortality was observed during the whole experimental period. Non significant changes were observed in blood and organ electrolytes (Calcium, Potassium and Sodium) level. Conclusion: Herbal syrup Linkus has produced no toxic effect at the administered doses neither showed any significant change in the electrolytes level in the blood and vital organs. https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/205Cough, Electrolytes, Gross toxicity, Herbal syrup, LD50, Linkus |
| spellingShingle | Riffat Farooqui Rafeeq Alam Khan Tahira Zamir Nasim Karim Effect of Herbal Syrup Linkus on Acute and Gross Toxicity and Electrolytes in Blood and Organs Journal of Bahria University Medical and Dental College Cough, Electrolytes, Gross toxicity, Herbal syrup, LD50, Linkus |
| title | Effect of Herbal Syrup Linkus on Acute and Gross Toxicity and Electrolytes in Blood and Organs |
| title_full | Effect of Herbal Syrup Linkus on Acute and Gross Toxicity and Electrolytes in Blood and Organs |
| title_fullStr | Effect of Herbal Syrup Linkus on Acute and Gross Toxicity and Electrolytes in Blood and Organs |
| title_full_unstemmed | Effect of Herbal Syrup Linkus on Acute and Gross Toxicity and Electrolytes in Blood and Organs |
| title_short | Effect of Herbal Syrup Linkus on Acute and Gross Toxicity and Electrolytes in Blood and Organs |
| title_sort | effect of herbal syrup linkus on acute and gross toxicity and electrolytes in blood and organs |
| topic | Cough, Electrolytes, Gross toxicity, Herbal syrup, LD50, Linkus |
| url | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/205 |
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