Human papillomavirus infection and anal cytology in Taiwanese homosexual men with and without HIV infection
Introduction: Anal cancer screening has not been adopted by Taiwanese care providers. The study aim was to explore the differences of anal cytology and HPV detection among men with and without HIV. Methodology: In this case-control study, men with HIV who attended one of the outpatient clinics o...
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The Journal of Infection in Developing Countries
2019-04-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/11162 |
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| author | Chi-Chao Wang Shih-Lung Chang Fang-Yeh Chu Chien-Yu Cheng Shu-Hsing Cheng |
| author_facet | Chi-Chao Wang Shih-Lung Chang Fang-Yeh Chu Chien-Yu Cheng Shu-Hsing Cheng |
| author_sort | Chi-Chao Wang |
| collection | DOAJ |
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Introduction: Anal cancer screening has not been adopted by Taiwanese care providers. The study aim was to explore the differences of anal cytology and HPV detection among men with and without HIV.
Methodology: In this case-control study, men with HIV who attended one of the outpatient clinics of Taoyuan General Hospital were enrolled as cases. Men who had experienced condomless sex and tested HIV negative were enrolled as controls. Anal swabs were collected for thin-preparation anal cytology and HPV genotyping.
Results: A total of 288 men who had tested positive for HIV and 208 who had tested HIV negative were enrolled; 75% of subjects with HIV and 30.3% of those without HIV had tested positive for various types of HPV (P < 0.001). Anal cell dysplasia, including atypical squamous cells with undetermined significance (ASCUS), low-grade squamous intraepithelial lesions (LSILs), high-grade squamous intraepithelial lesions (HSILs), or atypical squamous cells cannot exclude HSIL (ASC-H), were noted in 20.8% of men with HIV and 4.8% of those without HIV (P < 0.001). In multivariate analysis, HIV serostatus, history of sexually transmitted infections, having male sexual partners, and practice of anal sex were correlated significantly with detection of any type of HPV. Additionally, both oncogenic and non-oncogenic HPV types were significantly associated with anal cytology dysplasia.
Conclusions: We strongly suggest that there should be awareness of anal HPV infection and related anal cellular dysplasia in at-risk populations.
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| format | Article |
| id | doaj-art-7dc38e9089c34fe0b8d2d6905976a7cb |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2019-04-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-7dc38e9089c34fe0b8d2d6905976a7cb2025-08-20T02:57:53ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802019-04-01130410.3855/jidc.11162Human papillomavirus infection and anal cytology in Taiwanese homosexual men with and without HIV infectionChi-Chao Wang0Shih-Lung Chang1Fang-Yeh Chu2Chien-Yu Cheng3Shu-Hsing Cheng4Department of Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, TaiwanDepartment of Pathology, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, TaiwanDepartment of Clinical Pathology, Far Eastern Memorial Hospital, New Taipei City, TaiwanDepartment of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, TaiwanDepartment of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan Introduction: Anal cancer screening has not been adopted by Taiwanese care providers. The study aim was to explore the differences of anal cytology and HPV detection among men with and without HIV. Methodology: In this case-control study, men with HIV who attended one of the outpatient clinics of Taoyuan General Hospital were enrolled as cases. Men who had experienced condomless sex and tested HIV negative were enrolled as controls. Anal swabs were collected for thin-preparation anal cytology and HPV genotyping. Results: A total of 288 men who had tested positive for HIV and 208 who had tested HIV negative were enrolled; 75% of subjects with HIV and 30.3% of those without HIV had tested positive for various types of HPV (P < 0.001). Anal cell dysplasia, including atypical squamous cells with undetermined significance (ASCUS), low-grade squamous intraepithelial lesions (LSILs), high-grade squamous intraepithelial lesions (HSILs), or atypical squamous cells cannot exclude HSIL (ASC-H), were noted in 20.8% of men with HIV and 4.8% of those without HIV (P < 0.001). In multivariate analysis, HIV serostatus, history of sexually transmitted infections, having male sexual partners, and practice of anal sex were correlated significantly with detection of any type of HPV. Additionally, both oncogenic and non-oncogenic HPV types were significantly associated with anal cytology dysplasia. Conclusions: We strongly suggest that there should be awareness of anal HPV infection and related anal cellular dysplasia in at-risk populations. https://jidc.org/index.php/journal/article/view/11162HIVHPVASCUSmen who have sex with men |
| spellingShingle | Chi-Chao Wang Shih-Lung Chang Fang-Yeh Chu Chien-Yu Cheng Shu-Hsing Cheng Human papillomavirus infection and anal cytology in Taiwanese homosexual men with and without HIV infection Journal of Infection in Developing Countries HIV HPV ASCUS men who have sex with men |
| title | Human papillomavirus infection and anal cytology in Taiwanese homosexual men with and without HIV infection |
| title_full | Human papillomavirus infection and anal cytology in Taiwanese homosexual men with and without HIV infection |
| title_fullStr | Human papillomavirus infection and anal cytology in Taiwanese homosexual men with and without HIV infection |
| title_full_unstemmed | Human papillomavirus infection and anal cytology in Taiwanese homosexual men with and without HIV infection |
| title_short | Human papillomavirus infection and anal cytology in Taiwanese homosexual men with and without HIV infection |
| title_sort | human papillomavirus infection and anal cytology in taiwanese homosexual men with and without hiv infection |
| topic | HIV HPV ASCUS men who have sex with men |
| url | https://jidc.org/index.php/journal/article/view/11162 |
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