Prevalence of adherence to oral antidiabetic drugs in patients with type 2 diabetes: A systematic review and meta‐analysis
ABSTRACT Introduction The treatment of type 2 diabetes requires multidimensional management, with medication adherence a crucial aspect of diabetes control. However, recent rigorous estimates of adherence to oral antidiabetic drugs (OAD) are lacking. The objective of this study is to determine the p...
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| Format: | Article |
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Wiley
2024-11-01
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| Series: | Journal of Diabetes Investigation |
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| Online Access: | https://doi.org/10.1111/jdi.14285 |
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| author | Kansak Boonpattharatthiti Pirune Na Songkla Junpen Chantara Chanchanok Koomsri Ines Krass Nathorn Chaiyakunapruk Teerapon Dhippayom |
| author_facet | Kansak Boonpattharatthiti Pirune Na Songkla Junpen Chantara Chanchanok Koomsri Ines Krass Nathorn Chaiyakunapruk Teerapon Dhippayom |
| author_sort | Kansak Boonpattharatthiti |
| collection | DOAJ |
| description | ABSTRACT Introduction The treatment of type 2 diabetes requires multidimensional management, with medication adherence a crucial aspect of diabetes control. However, recent rigorous estimates of adherence to oral antidiabetic drugs (OAD) are lacking. The objective of this study is to determine the prevalence of adherence to OAD in type 2 diabetes patients. Methods A systematic search was performed in PubMed, EMBASE, PsycINFO, and CINAHL from July 2013 to April 2023. Cross‐sectional studies published in English were included if they met the following criteria: (1) reported the adherence to OAD using a validated measure; and (2) had a sample size of at least 385 patients with type 2 diabetes. The Joanna Briggs Institute critical appraisal for studies reporting prevalence data was used to assess the quality of the included studies. Pooled estimates of the prevalence of adherence to OAD were calculated as a percentage together with 95% confidence interval (95% CI) using a random‐effect model. All analyses were conducted using STATA 17.0; PROSPERO (CRD42023414264). Results Twenty‐six studies involving a total of 69,366 patients met the selection criteria and were included in the meta‐analysis. The overall estimated prevalence of adherence to OAD was 55.53% (95%CI: 44.22%–66.85%). Among the included studies, nine were deemed to be of high quality. A sensitivity analysis conducted using only the high‐quality studies revealed a prevalence of adherence to OAD at 52.24% (95% CI: 39.63%–64.85%). Conclusions The overall prevalence of adherence to OAD was remarkably low among type 2 diabetes patients worldwide. Healthcare practitioners and policy makers should employ appropriate approaches to improve adherence to OAD. |
| format | Article |
| id | doaj-art-7dc0666b89e34698b174768c501609ac |
| institution | OA Journals |
| issn | 2040-1116 2040-1124 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj-art-7dc0666b89e34698b174768c501609ac2025-08-20T01:47:25ZengWileyJournal of Diabetes Investigation2040-11162040-11242024-11-0115111614162510.1111/jdi.14285Prevalence of adherence to oral antidiabetic drugs in patients with type 2 diabetes: A systematic review and meta‐analysisKansak Boonpattharatthiti0Pirune Na Songkla1Junpen Chantara2Chanchanok Koomsri3Ines Krass4Nathorn Chaiyakunapruk5Teerapon Dhippayom6Faculty of Pharmaceutical Sciences Burapha University Chon buri ThailandThe Research Unit of Evidence Synthesis (TRUES), Faculty of Pharmaceutical Sciences Naresuan University Phitsanulok ThailandThe Research Unit of Evidence Synthesis (TRUES), Faculty of Pharmaceutical Sciences Naresuan University Phitsanulok ThailandThe Research Unit of Evidence Synthesis (TRUES), Faculty of Pharmaceutical Sciences Naresuan University Phitsanulok ThailandSchool of Pharmacy The University of Sydney Sydney New South Wales AustraliaDepartment of Pharmacotherapy, College of Pharmacy University of Utah Salt Lake City Utah USAThe Research Unit of Evidence Synthesis (TRUES), Faculty of Pharmaceutical Sciences Naresuan University Phitsanulok ThailandABSTRACT Introduction The treatment of type 2 diabetes requires multidimensional management, with medication adherence a crucial aspect of diabetes control. However, recent rigorous estimates of adherence to oral antidiabetic drugs (OAD) are lacking. The objective of this study is to determine the prevalence of adherence to OAD in type 2 diabetes patients. Methods A systematic search was performed in PubMed, EMBASE, PsycINFO, and CINAHL from July 2013 to April 2023. Cross‐sectional studies published in English were included if they met the following criteria: (1) reported the adherence to OAD using a validated measure; and (2) had a sample size of at least 385 patients with type 2 diabetes. The Joanna Briggs Institute critical appraisal for studies reporting prevalence data was used to assess the quality of the included studies. Pooled estimates of the prevalence of adherence to OAD were calculated as a percentage together with 95% confidence interval (95% CI) using a random‐effect model. All analyses were conducted using STATA 17.0; PROSPERO (CRD42023414264). Results Twenty‐six studies involving a total of 69,366 patients met the selection criteria and were included in the meta‐analysis. The overall estimated prevalence of adherence to OAD was 55.53% (95%CI: 44.22%–66.85%). Among the included studies, nine were deemed to be of high quality. A sensitivity analysis conducted using only the high‐quality studies revealed a prevalence of adherence to OAD at 52.24% (95% CI: 39.63%–64.85%). Conclusions The overall prevalence of adherence to OAD was remarkably low among type 2 diabetes patients worldwide. Healthcare practitioners and policy makers should employ appropriate approaches to improve adherence to OAD.https://doi.org/10.1111/jdi.14285AdherencesDiabetesOral antidiabetic drugs |
| spellingShingle | Kansak Boonpattharatthiti Pirune Na Songkla Junpen Chantara Chanchanok Koomsri Ines Krass Nathorn Chaiyakunapruk Teerapon Dhippayom Prevalence of adherence to oral antidiabetic drugs in patients with type 2 diabetes: A systematic review and meta‐analysis Journal of Diabetes Investigation Adherences Diabetes Oral antidiabetic drugs |
| title | Prevalence of adherence to oral antidiabetic drugs in patients with type 2 diabetes: A systematic review and meta‐analysis |
| title_full | Prevalence of adherence to oral antidiabetic drugs in patients with type 2 diabetes: A systematic review and meta‐analysis |
| title_fullStr | Prevalence of adherence to oral antidiabetic drugs in patients with type 2 diabetes: A systematic review and meta‐analysis |
| title_full_unstemmed | Prevalence of adherence to oral antidiabetic drugs in patients with type 2 diabetes: A systematic review and meta‐analysis |
| title_short | Prevalence of adherence to oral antidiabetic drugs in patients with type 2 diabetes: A systematic review and meta‐analysis |
| title_sort | prevalence of adherence to oral antidiabetic drugs in patients with type 2 diabetes a systematic review and meta analysis |
| topic | Adherences Diabetes Oral antidiabetic drugs |
| url | https://doi.org/10.1111/jdi.14285 |
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