Advanced Imaging Modalities in the Detection of Cerebral Vasospasm
The pathophysiology of cerebral vasospasm following aneurysmal subarachnoid hemorrhage (SAH) is complex and is not entirely understood. Mechanistic insights have been gained through advances in the capabilities of diagnostic imaging. Core techniques have focused on the assessment of vessel caliber,...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2013/415960 |
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| _version_ | 1832558809153798144 |
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| author | Jena N. Mills Vivek Mehta Jonathan Russin Arun P. Amar Anandh Rajamohan William J. Mack |
| author_facet | Jena N. Mills Vivek Mehta Jonathan Russin Arun P. Amar Anandh Rajamohan William J. Mack |
| author_sort | Jena N. Mills |
| collection | DOAJ |
| description | The pathophysiology of cerebral vasospasm following aneurysmal subarachnoid hemorrhage (SAH) is complex and is not entirely understood. Mechanistic insights have been gained through advances in the capabilities of diagnostic imaging. Core techniques have focused on the assessment of vessel caliber, tissue metabolism, and/or regional perfusion parameters. Advances in imaging have provided clinicians with a multifaceted approach to assist in the detection of cerebral vasospasm and the diagnosis of delayed ischemic neurologic deficits (DIND). However, a single test or algorithm with broad efficacy remains elusive. This paper examines both anatomical and physiological imaging modalities applicable to post-SAH vasospasm and offers a historical background. We consider cerebral blood flow velocities measured by Transcranial Doppler Ultrasonography (TCD). Structural imaging techniques, including catheter-based Digital Subtraction Angiography (DSA), CT Angiography (CTA), and MR Angiography (MRA), are reviewed. We examine physiologic assessment by PET, HMPAO SPECT, 133Xe Clearance, Xenon-Enhanced CT (Xe/CT), Perfusion CT (PCT), and Diffusion-Weighted/MR Perfusion Imaging. Comparative advantages and limitations are discussed. |
| format | Article |
| id | doaj-art-7dbea81412d9472db76641ae6c57fbae |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-7dbea81412d9472db76641ae6c57fbae2025-02-03T01:31:36ZengWileyNeurology Research International2090-18522090-18602013-01-01201310.1155/2013/415960415960Advanced Imaging Modalities in the Detection of Cerebral VasospasmJena N. Mills0Vivek Mehta1Jonathan Russin2Arun P. Amar3Anandh Rajamohan4William J. Mack5Department of Neurosurgery, University of Southern California, 1200 North State Street, Suite 3300, Los Angeles, CA 90033, USADepartment of Neurosurgery, University of Southern California, 1200 North State Street, Suite 3300, Los Angeles, CA 90033, USADepartment of Neurosurgery, University of Southern California, 1200 North State Street, Suite 3300, Los Angeles, CA 90033, USADepartment of Neurosurgery, University of Southern California, 1200 North State Street, Suite 3300, Los Angeles, CA 90033, USADepartment of Radiology, University of Southern California, 1200 North State Street, Suite 3300, Los Angeles, CA 90033, USADepartment of Neurosurgery, University of Southern California, 1200 North State Street, Suite 3300, Los Angeles, CA 90033, USAThe pathophysiology of cerebral vasospasm following aneurysmal subarachnoid hemorrhage (SAH) is complex and is not entirely understood. Mechanistic insights have been gained through advances in the capabilities of diagnostic imaging. Core techniques have focused on the assessment of vessel caliber, tissue metabolism, and/or regional perfusion parameters. Advances in imaging have provided clinicians with a multifaceted approach to assist in the detection of cerebral vasospasm and the diagnosis of delayed ischemic neurologic deficits (DIND). However, a single test or algorithm with broad efficacy remains elusive. This paper examines both anatomical and physiological imaging modalities applicable to post-SAH vasospasm and offers a historical background. We consider cerebral blood flow velocities measured by Transcranial Doppler Ultrasonography (TCD). Structural imaging techniques, including catheter-based Digital Subtraction Angiography (DSA), CT Angiography (CTA), and MR Angiography (MRA), are reviewed. We examine physiologic assessment by PET, HMPAO SPECT, 133Xe Clearance, Xenon-Enhanced CT (Xe/CT), Perfusion CT (PCT), and Diffusion-Weighted/MR Perfusion Imaging. Comparative advantages and limitations are discussed.http://dx.doi.org/10.1155/2013/415960 |
| spellingShingle | Jena N. Mills Vivek Mehta Jonathan Russin Arun P. Amar Anandh Rajamohan William J. Mack Advanced Imaging Modalities in the Detection of Cerebral Vasospasm Neurology Research International |
| title | Advanced Imaging Modalities in the Detection of Cerebral Vasospasm |
| title_full | Advanced Imaging Modalities in the Detection of Cerebral Vasospasm |
| title_fullStr | Advanced Imaging Modalities in the Detection of Cerebral Vasospasm |
| title_full_unstemmed | Advanced Imaging Modalities in the Detection of Cerebral Vasospasm |
| title_short | Advanced Imaging Modalities in the Detection of Cerebral Vasospasm |
| title_sort | advanced imaging modalities in the detection of cerebral vasospasm |
| url | http://dx.doi.org/10.1155/2013/415960 |
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