Current Controversies in Newer Therapies to Treat Birth Asphyxia
Despite major advances in monitoring technology and knowledge of fetal and neonatal pathophysiology, neonatal hypoxic-ischemic encephalopathy (HIE) remains one of the main causes of severe adverse neurological outcome in children. Until recently, there were no therapies other than supportive measure...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2011/848413 |
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| author | Pia Wintermark |
| author_facet | Pia Wintermark |
| author_sort | Pia Wintermark |
| collection | DOAJ |
| description | Despite major advances in monitoring technology and knowledge of fetal and neonatal pathophysiology, neonatal hypoxic-ischemic encephalopathy (HIE) remains one of the main causes of severe adverse neurological outcome in children. Until recently, there were no therapies other than supportive measures. Over the past several years, mild hypothermia has been proven to be safe to treat HIE. Unfortunately, this neuroprotective strategy seems efficient in preventing brain injury in some asphyxiated newborns, but not in all of them. Thus, there is increasing interest to rapidly understand how to refine hypothermia therapy and add neuroprotective or neurorestorative strategies. Several promising newer treatments to treat birth asphyxia and prevent its devastating neurological consequences are currently being tested. In this paper, the physiopathology behind HIE, the currently available treatment, the potential alternatives, and the next steps before implementation of these other treatments are reviewed. |
| format | Article |
| id | doaj-art-7db7e3caae2842e8a4ac4d018c1f19c1 |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-7db7e3caae2842e8a4ac4d018c1f19c12025-02-03T01:31:56ZengWileyInternational Journal of Pediatrics1687-97401687-97592011-01-01201110.1155/2011/848413848413Current Controversies in Newer Therapies to Treat Birth AsphyxiaPia Wintermark0Division of Newborn Medicine, Montreal Children's Hospital, McGill University, 2300 Rue Tupper, C-920, Montreal, QC, H3H 1P3, CanadaDespite major advances in monitoring technology and knowledge of fetal and neonatal pathophysiology, neonatal hypoxic-ischemic encephalopathy (HIE) remains one of the main causes of severe adverse neurological outcome in children. Until recently, there were no therapies other than supportive measures. Over the past several years, mild hypothermia has been proven to be safe to treat HIE. Unfortunately, this neuroprotective strategy seems efficient in preventing brain injury in some asphyxiated newborns, but not in all of them. Thus, there is increasing interest to rapidly understand how to refine hypothermia therapy and add neuroprotective or neurorestorative strategies. Several promising newer treatments to treat birth asphyxia and prevent its devastating neurological consequences are currently being tested. In this paper, the physiopathology behind HIE, the currently available treatment, the potential alternatives, and the next steps before implementation of these other treatments are reviewed.http://dx.doi.org/10.1155/2011/848413 |
| spellingShingle | Pia Wintermark Current Controversies in Newer Therapies to Treat Birth Asphyxia International Journal of Pediatrics |
| title | Current Controversies in Newer Therapies to Treat Birth Asphyxia |
| title_full | Current Controversies in Newer Therapies to Treat Birth Asphyxia |
| title_fullStr | Current Controversies in Newer Therapies to Treat Birth Asphyxia |
| title_full_unstemmed | Current Controversies in Newer Therapies to Treat Birth Asphyxia |
| title_short | Current Controversies in Newer Therapies to Treat Birth Asphyxia |
| title_sort | current controversies in newer therapies to treat birth asphyxia |
| url | http://dx.doi.org/10.1155/2011/848413 |
| work_keys_str_mv | AT piawintermark currentcontroversiesinnewertherapiestotreatbirthasphyxia |