PKM2, a Central Point of Regulation in Cancer Metabolism
Aerobic glycolysis is the dominant metabolic pathway utilized by cancer cells, owing to its ability to divert glucose metabolites from ATP production towards the synthesis of cellular building blocks (nucleotides, amino acids, and lipids) to meet the demands of proliferation. The M2 isoform of pyruv...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2013/242513 |
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| author | Nicholas Wong Jason De Melo Damu Tang |
| author_facet | Nicholas Wong Jason De Melo Damu Tang |
| author_sort | Nicholas Wong |
| collection | DOAJ |
| description | Aerobic glycolysis is the dominant metabolic pathway utilized by cancer cells, owing to its ability to divert glucose metabolites from ATP production towards the synthesis of cellular building blocks (nucleotides, amino acids, and lipids) to meet the demands of proliferation. The M2 isoform of pyruvate kinase (PKM2) catalyzes the final and also a rate-limiting reaction in the glycolytic pathway. In the PK family, PKM2 is subjected to a complex regulation by both oncogenes and tumour suppressors, which allows for a fine-tone regulation of PKM2 activity. The less active form of PKM2 drives glucose through the route of aerobic glycolysis, while active PKM2 directs glucose towards oxidative metabolism. Additionally, PKM2 possesses protein tyrosine kinase activity and plays a role in modulating gene expression and thereby contributing to tumorigenesis. We will discuss our current understanding of PKM2's regulation and its many contributions to tumorigenesis. |
| format | Article |
| id | doaj-art-7db3fa9e83bc409cbd9fa12630c95e5d |
| institution | OA Journals |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-7db3fa9e83bc409cbd9fa12630c95e5d2025-08-20T02:07:38ZengWileyInternational Journal of Cell Biology1687-88761687-88842013-01-01201310.1155/2013/242513242513PKM2, a Central Point of Regulation in Cancer MetabolismNicholas Wong0Jason De Melo1Damu Tang2Division of Nephrology, Department of Medicine, McMaster University, Hamilton, ON, L8S 4L8, CanadaDivision of Nephrology, Department of Medicine, McMaster University, Hamilton, ON, L8S 4L8, CanadaDivision of Nephrology, Department of Medicine, McMaster University, Hamilton, ON, L8S 4L8, CanadaAerobic glycolysis is the dominant metabolic pathway utilized by cancer cells, owing to its ability to divert glucose metabolites from ATP production towards the synthesis of cellular building blocks (nucleotides, amino acids, and lipids) to meet the demands of proliferation. The M2 isoform of pyruvate kinase (PKM2) catalyzes the final and also a rate-limiting reaction in the glycolytic pathway. In the PK family, PKM2 is subjected to a complex regulation by both oncogenes and tumour suppressors, which allows for a fine-tone regulation of PKM2 activity. The less active form of PKM2 drives glucose through the route of aerobic glycolysis, while active PKM2 directs glucose towards oxidative metabolism. Additionally, PKM2 possesses protein tyrosine kinase activity and plays a role in modulating gene expression and thereby contributing to tumorigenesis. We will discuss our current understanding of PKM2's regulation and its many contributions to tumorigenesis.http://dx.doi.org/10.1155/2013/242513 |
| spellingShingle | Nicholas Wong Jason De Melo Damu Tang PKM2, a Central Point of Regulation in Cancer Metabolism International Journal of Cell Biology |
| title | PKM2, a Central Point of Regulation in Cancer Metabolism |
| title_full | PKM2, a Central Point of Regulation in Cancer Metabolism |
| title_fullStr | PKM2, a Central Point of Regulation in Cancer Metabolism |
| title_full_unstemmed | PKM2, a Central Point of Regulation in Cancer Metabolism |
| title_short | PKM2, a Central Point of Regulation in Cancer Metabolism |
| title_sort | pkm2 a central point of regulation in cancer metabolism |
| url | http://dx.doi.org/10.1155/2013/242513 |
| work_keys_str_mv | AT nicholaswong pkm2acentralpointofregulationincancermetabolism AT jasondemelo pkm2acentralpointofregulationincancermetabolism AT damutang pkm2acentralpointofregulationincancermetabolism |