Tissue Engineered Strategies for Skeletal Muscle Injury
Skeletal muscle injuries are common in athletes, occurring with direct and indirect mechanisms and marked residual effects, such as severe long-term pain and physical disability. Current therapy consists of conservative management including RICE protocol (rest, ice, compression, and elevation), nons...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2012/175038 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550984068366336 |
|---|---|
| author | Umile Giuseppe Longo Mattia Loppini Alessandra Berton Filippo Spiezia Nicola Maffulli Vincenzo Denaro |
| author_facet | Umile Giuseppe Longo Mattia Loppini Alessandra Berton Filippo Spiezia Nicola Maffulli Vincenzo Denaro |
| author_sort | Umile Giuseppe Longo |
| collection | DOAJ |
| description | Skeletal muscle injuries are common in athletes, occurring with direct and indirect mechanisms and marked residual effects, such as severe long-term pain and physical disability. Current therapy consists of conservative management including RICE protocol (rest, ice, compression, and elevation), nonsteroidal anti-inflammatory drugs, and intramuscular corticosteroids. However, current management of muscle injuries often does not provide optimal restoration to preinjury status. New biological therapies, such as injection of platelet-rich plasma and stem-cell-based therapy, are appealing. Although some studies support PRP application in muscle-injury management, reasons for concern persist, and further research is required for a standardized and safe use of PRP in clinical practice. The role of stem cells needs to be confirmed, as studies are still limited and inconsistent. Further research is needed to identify mechanisms involved in muscle regeneration and in survival, proliferation, and differentiation of stem cells. |
| format | Article |
| id | doaj-art-7dab911d4b7a4693ab874133a00da84c |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-7dab911d4b7a4693ab874133a00da84c2025-02-03T06:05:22ZengWileyStem Cells International1687-966X1687-96782012-01-01201210.1155/2012/175038175038Tissue Engineered Strategies for Skeletal Muscle InjuryUmile Giuseppe Longo0Mattia Loppini1Alessandra Berton2Filippo Spiezia3Nicola Maffulli4Vincenzo Denaro5Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo 200, Trigoria, 00128 Rome, ItalyDepartment of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo 200, Trigoria, 00128 Rome, ItalyDepartment of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo 200, Trigoria, 00128 Rome, ItalyDepartment of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo 200, Trigoria, 00128 Rome, ItalyCentre for Sports and Exercise Medicine, Barts and The London School of Medicine and Dentistry, Mile End Hospital, 275 Bancroft Road, London E1 4DG, UKDepartment of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo 200, Trigoria, 00128 Rome, ItalySkeletal muscle injuries are common in athletes, occurring with direct and indirect mechanisms and marked residual effects, such as severe long-term pain and physical disability. Current therapy consists of conservative management including RICE protocol (rest, ice, compression, and elevation), nonsteroidal anti-inflammatory drugs, and intramuscular corticosteroids. However, current management of muscle injuries often does not provide optimal restoration to preinjury status. New biological therapies, such as injection of platelet-rich plasma and stem-cell-based therapy, are appealing. Although some studies support PRP application in muscle-injury management, reasons for concern persist, and further research is required for a standardized and safe use of PRP in clinical practice. The role of stem cells needs to be confirmed, as studies are still limited and inconsistent. Further research is needed to identify mechanisms involved in muscle regeneration and in survival, proliferation, and differentiation of stem cells.http://dx.doi.org/10.1155/2012/175038 |
| spellingShingle | Umile Giuseppe Longo Mattia Loppini Alessandra Berton Filippo Spiezia Nicola Maffulli Vincenzo Denaro Tissue Engineered Strategies for Skeletal Muscle Injury Stem Cells International |
| title | Tissue Engineered Strategies for Skeletal Muscle Injury |
| title_full | Tissue Engineered Strategies for Skeletal Muscle Injury |
| title_fullStr | Tissue Engineered Strategies for Skeletal Muscle Injury |
| title_full_unstemmed | Tissue Engineered Strategies for Skeletal Muscle Injury |
| title_short | Tissue Engineered Strategies for Skeletal Muscle Injury |
| title_sort | tissue engineered strategies for skeletal muscle injury |
| url | http://dx.doi.org/10.1155/2012/175038 |
| work_keys_str_mv | AT umilegiuseppelongo tissueengineeredstrategiesforskeletalmuscleinjury AT mattialoppini tissueengineeredstrategiesforskeletalmuscleinjury AT alessandraberton tissueengineeredstrategiesforskeletalmuscleinjury AT filippospiezia tissueengineeredstrategiesforskeletalmuscleinjury AT nicolamaffulli tissueengineeredstrategiesforskeletalmuscleinjury AT vincenzodenaro tissueengineeredstrategiesforskeletalmuscleinjury |