A Study on Cough Sensitivity and Airway Inflammation in Patients with Sinobronchial Syndrome
Objective. This study aimed to clarify the characteristics of cough-reflex sensitivity and airway inflammation in patients with sinobronchial syndrome (SBS). Methods. 39 patients with SBS, 53 patients with upper airway cough syndrome (UACS) induced by rhinitis, 33 patients with chronic sinusitis wit...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2022/2726261 |
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| author | Shengyuan Wang Shanshan Niu Siwan Wen Mengru Zhang Cuiqin Shi Zhongmin Qiu Li Yu Xianghuai Xu |
| author_facet | Shengyuan Wang Shanshan Niu Siwan Wen Mengru Zhang Cuiqin Shi Zhongmin Qiu Li Yu Xianghuai Xu |
| author_sort | Shengyuan Wang |
| collection | DOAJ |
| description | Objective. This study aimed to clarify the characteristics of cough-reflex sensitivity and airway inflammation in patients with sinobronchial syndrome (SBS). Methods. 39 patients with SBS, 53 patients with upper airway cough syndrome (UACS) induced by rhinitis, 33 patients with chronic sinusitis without cough, and 39 healthy controls (HCs) were enrolled between January 2013 and December 2018. All participants underwent a capsaicin cough-sensitivity test and cytology of induced sputum. The concentration of calcitonin-gene-related peptide (CGPR), histamine, prostaglandin (PG) E2, and eosinophil cationic protein (ECP) in induced sputum were measured using enzyme-linked immunosorbent assays (ELISAs). Results. The lowest concentration of capsaicin solution that induced ≥5 coughs (C5) was decreased markedly in patients with UACS induced by rhinitis compared with SBS patients (1.95 ± 2.92 vs. 31.2 ± 58.6 mol/L, P<0.001), indicating higher cough-reflex sensitivity among UACS patients induced by rhinitis. However, there was no difference of these threshold between SBS patients and patients with sinusitis without cough and HCs. The percentage of neutrophils in sputum was increased remarkably in patients with SBS compared with HCs (40.0 ± 48.5% vs. 5.5 ± 9.0%, P<0.001). A higher concentration of CGPR, histamine, and PGE2 was observed in induced sputum from patients with UACS induced by rhinitis than that in controls, and the ECP level was increased significantly in UACS induced by rhinitis compared with that in the other three groups. Conclusions. Cough-reflex sensitivity and airway inflammation in patients with SBS were different in patients with UACS induced by rhinitis. Thus, the mechanism of cough in those two patient populations might differ. Our study is registered in the Chinese Clinical Trials Register (https://www.chictr.org.cn/) as ChiCTR-TRC-00000152. |
| format | Article |
| id | doaj-art-7da127935bae40f599eda5dce32c50f4 |
| institution | Kabale University |
| issn | 1916-7245 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-7da127935bae40f599eda5dce32c50f42025-08-20T03:35:24ZengWileyCanadian Respiratory Journal1916-72452022-01-01202210.1155/2022/2726261A Study on Cough Sensitivity and Airway Inflammation in Patients with Sinobronchial SyndromeShengyuan Wang0Shanshan Niu1Siwan Wen2Mengru Zhang3Cuiqin Shi4Zhongmin Qiu5Li Yu6Xianghuai Xu7Department of Pulmonary and Critical Care MedicineDepartment of Pulmonary and Critical Care MedicineDepartment of Pulmonary and Critical Care MedicineDepartment of Pulmonary and Critical Care MedicineDepartment of Pulmonary and Critical Care MedicineDepartment of Pulmonary and Critical Care MedicineDepartment of Pulmonary and Critical Care MedicineDepartment of Pulmonary and Critical Care MedicineObjective. This study aimed to clarify the characteristics of cough-reflex sensitivity and airway inflammation in patients with sinobronchial syndrome (SBS). Methods. 39 patients with SBS, 53 patients with upper airway cough syndrome (UACS) induced by rhinitis, 33 patients with chronic sinusitis without cough, and 39 healthy controls (HCs) were enrolled between January 2013 and December 2018. All participants underwent a capsaicin cough-sensitivity test and cytology of induced sputum. The concentration of calcitonin-gene-related peptide (CGPR), histamine, prostaglandin (PG) E2, and eosinophil cationic protein (ECP) in induced sputum were measured using enzyme-linked immunosorbent assays (ELISAs). Results. The lowest concentration of capsaicin solution that induced ≥5 coughs (C5) was decreased markedly in patients with UACS induced by rhinitis compared with SBS patients (1.95 ± 2.92 vs. 31.2 ± 58.6 mol/L, P<0.001), indicating higher cough-reflex sensitivity among UACS patients induced by rhinitis. However, there was no difference of these threshold between SBS patients and patients with sinusitis without cough and HCs. The percentage of neutrophils in sputum was increased remarkably in patients with SBS compared with HCs (40.0 ± 48.5% vs. 5.5 ± 9.0%, P<0.001). A higher concentration of CGPR, histamine, and PGE2 was observed in induced sputum from patients with UACS induced by rhinitis than that in controls, and the ECP level was increased significantly in UACS induced by rhinitis compared with that in the other three groups. Conclusions. Cough-reflex sensitivity and airway inflammation in patients with SBS were different in patients with UACS induced by rhinitis. Thus, the mechanism of cough in those two patient populations might differ. Our study is registered in the Chinese Clinical Trials Register (https://www.chictr.org.cn/) as ChiCTR-TRC-00000152.http://dx.doi.org/10.1155/2022/2726261 |
| spellingShingle | Shengyuan Wang Shanshan Niu Siwan Wen Mengru Zhang Cuiqin Shi Zhongmin Qiu Li Yu Xianghuai Xu A Study on Cough Sensitivity and Airway Inflammation in Patients with Sinobronchial Syndrome Canadian Respiratory Journal |
| title | A Study on Cough Sensitivity and Airway Inflammation in Patients with Sinobronchial Syndrome |
| title_full | A Study on Cough Sensitivity and Airway Inflammation in Patients with Sinobronchial Syndrome |
| title_fullStr | A Study on Cough Sensitivity and Airway Inflammation in Patients with Sinobronchial Syndrome |
| title_full_unstemmed | A Study on Cough Sensitivity and Airway Inflammation in Patients with Sinobronchial Syndrome |
| title_short | A Study on Cough Sensitivity and Airway Inflammation in Patients with Sinobronchial Syndrome |
| title_sort | study on cough sensitivity and airway inflammation in patients with sinobronchial syndrome |
| url | http://dx.doi.org/10.1155/2022/2726261 |
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