Distinct pathways for genetic and epigenetic predisposition in familial and bilateral Wilms tumor

Distinct pathways for genetic and epigenetic predisposition in familial and bilateral Wilms tumor

Abstract Background Genetic predisposition is particularly common in children with the kidney cancer, Wilms tumor. In 10% of these children, this manifests as a family history of Wilms tumor or bilateral disease. The frequency and spectrum of underlying changes have not been systematically investiga...

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Main Authors: Jenny Wegert, Silke Appenzeller, Taryn D. Treger, Heike Streitenberger, Barbara Ziegler, Sabrina Bausenwein, Christian Vokuhl, Conor Parks, Eva Jüttner, Susanne Gramlich, Karen Ernestus, Steven W. Warman, Jörg Fuchs, Jochen Hubertus, Dietrich von Schweinitz, Birgit Fröhlich, Norbert Jorch, Ralf Knöfler, Carsten Friedrich, Selim Corbacioglu, Michael C. Frühwald, Arnulf Pekrun, Dominik T. Schneider, Jörg Faber, Jana Stursberg, Markus Metzler, Nils Welter, Kathy Pritchard-Jones, Norbert Graf, Rhoikos Furtwängler, Sam Behjati, Manfred Gessler
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Genome Medicine
Subjects:
Wilms tumor
Nephroblastoma
Genomic imprinting
Hereditary cancer
Cancer predisposition
Pediatric cancer
Online Access:https://doi.org/10.1186/s13073-025-01482-0
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