Royal jelly acid: preparation, metabolism and therapeutic potential
Royal jelly acid (10-HDA), an unsaturated fatty acid unique to royal jelly, exhibits a diverse range of biological activities, including hypoglycemic, anti-inflammatory, and anticancer properties. In recent years, the increasing demand for natural product supplements as health enhancers has led to a...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1561351/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850125031047168000 |
|---|---|
| author | Dandan Zhi Xiying He Yunfei Xue Wenzheng Zhao Xueyang Gong Yulong Guo Xinming Luo Yakai Tian Kun Dong |
| author_facet | Dandan Zhi Xiying He Yunfei Xue Wenzheng Zhao Xueyang Gong Yulong Guo Xinming Luo Yakai Tian Kun Dong |
| author_sort | Dandan Zhi |
| collection | DOAJ |
| description | Royal jelly acid (10-HDA), an unsaturated fatty acid unique to royal jelly, exhibits a diverse range of biological activities, including hypoglycemic, anti-inflammatory, and anticancer properties. In recent years, the increasing demand for natural product supplements as health enhancers has led to a significant rise in the consumption of royal jelly products for daily wellness. Consequently, the market for royal jelly supplements has expanded considerably. Understanding the mechanisms underlying the biological activities of royal jelly acid is crucial for optimizing its therapeutic applications and guiding the development of innovative royal jelly-based products. This review consolidates current research on the preparation, metabolism and potential pharmacological roles of royal jelly acid in managing cancer, inflammatory disorders, and glucolipid metabolic diseases and explores the molecular mechanisms driving these effects. Future research should leverage advanced analytical techniques to uncover the intricate mechanisms of royal jelly acid’s actions, paving the way for its broader integration into healthcare and clinical settings. |
| format | Article |
| id | doaj-art-7d98ea6aba954f2684940e0e19bd7176 |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-7d98ea6aba954f2684940e0e19bd71762025-08-20T02:34:12ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-05-011610.3389/fphar.2025.15613511561351Royal jelly acid: preparation, metabolism and therapeutic potentialDandan Zhi0Xiying He1Yunfei Xue2Wenzheng Zhao3Xueyang Gong4Yulong Guo5Xinming Luo6Yakai Tian7Kun Dong8Yunnan Provincial Engineering and Research Center for Sustainable Utilization of Honey Bee Resources, Eastern Bee Research Institute, College of Animal Science and Technology, Yunnan Agricultural University, Kunming, ChinaFirst clinical medical College, Yunnan University of Chinese Medicine, Kunming, ChinaYunnan Provincial Engineering and Research Center for Sustainable Utilization of Honey Bee Resources, Eastern Bee Research Institute, College of Animal Science and Technology, Yunnan Agricultural University, Kunming, ChinaYunnan Provincial Engineering and Research Center for Sustainable Utilization of Honey Bee Resources, Eastern Bee Research Institute, College of Animal Science and Technology, Yunnan Agricultural University, Kunming, ChinaYunnan Provincial Engineering and Research Center for Sustainable Utilization of Honey Bee Resources, Eastern Bee Research Institute, College of Animal Science and Technology, Yunnan Agricultural University, Kunming, ChinaYunnan Provincial Engineering and Research Center for Sustainable Utilization of Honey Bee Resources, Eastern Bee Research Institute, College of Animal Science and Technology, Yunnan Agricultural University, Kunming, ChinaAgricultural and Rural Service Center in Wangjiafan Town, Yichang, Hubei, ChinaYunnan Provincial Engineering and Research Center for Sustainable Utilization of Honey Bee Resources, Eastern Bee Research Institute, College of Animal Science and Technology, Yunnan Agricultural University, Kunming, ChinaYunnan Provincial Engineering and Research Center for Sustainable Utilization of Honey Bee Resources, Eastern Bee Research Institute, College of Animal Science and Technology, Yunnan Agricultural University, Kunming, ChinaRoyal jelly acid (10-HDA), an unsaturated fatty acid unique to royal jelly, exhibits a diverse range of biological activities, including hypoglycemic, anti-inflammatory, and anticancer properties. In recent years, the increasing demand for natural product supplements as health enhancers has led to a significant rise in the consumption of royal jelly products for daily wellness. Consequently, the market for royal jelly supplements has expanded considerably. Understanding the mechanisms underlying the biological activities of royal jelly acid is crucial for optimizing its therapeutic applications and guiding the development of innovative royal jelly-based products. This review consolidates current research on the preparation, metabolism and potential pharmacological roles of royal jelly acid in managing cancer, inflammatory disorders, and glucolipid metabolic diseases and explores the molecular mechanisms driving these effects. Future research should leverage advanced analytical techniques to uncover the intricate mechanisms of royal jelly acid’s actions, paving the way for its broader integration into healthcare and clinical settings.https://www.frontiersin.org/articles/10.3389/fphar.2025.1561351/fullroyal jelly acid10-HDAfatty acidsfunctionpharmacological effects |
| spellingShingle | Dandan Zhi Xiying He Yunfei Xue Wenzheng Zhao Xueyang Gong Yulong Guo Xinming Luo Yakai Tian Kun Dong Royal jelly acid: preparation, metabolism and therapeutic potential Frontiers in Pharmacology royal jelly acid 10-HDA fatty acids function pharmacological effects |
| title | Royal jelly acid: preparation, metabolism and therapeutic potential |
| title_full | Royal jelly acid: preparation, metabolism and therapeutic potential |
| title_fullStr | Royal jelly acid: preparation, metabolism and therapeutic potential |
| title_full_unstemmed | Royal jelly acid: preparation, metabolism and therapeutic potential |
| title_short | Royal jelly acid: preparation, metabolism and therapeutic potential |
| title_sort | royal jelly acid preparation metabolism and therapeutic potential |
| topic | royal jelly acid 10-HDA fatty acids function pharmacological effects |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1561351/full |
| work_keys_str_mv | AT dandanzhi royaljellyacidpreparationmetabolismandtherapeuticpotential AT xiyinghe royaljellyacidpreparationmetabolismandtherapeuticpotential AT yunfeixue royaljellyacidpreparationmetabolismandtherapeuticpotential AT wenzhengzhao royaljellyacidpreparationmetabolismandtherapeuticpotential AT xueyanggong royaljellyacidpreparationmetabolismandtherapeuticpotential AT yulongguo royaljellyacidpreparationmetabolismandtherapeuticpotential AT xinmingluo royaljellyacidpreparationmetabolismandtherapeuticpotential AT yakaitian royaljellyacidpreparationmetabolismandtherapeuticpotential AT kundong royaljellyacidpreparationmetabolismandtherapeuticpotential |