Sleep Disorders in Children with Rett Syndrome
Rett syndrome (RTT) is an X-linked neurodevelopmental disorder marked by neurological regression, autonomic dysfunction, seizures, and significant sleep and breathing abnormalities. About 80% of affected individuals, especially young children, experience sleep disturbances such as insomnia, sleep-di...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-06-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/12/7/869 |
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| author | Christopher Harner Thomas A. Gaffey Shannon S. Sullivan Manisha Witmans Lourdes M. DelRosso Mary Anne Tablizo |
| author_facet | Christopher Harner Thomas A. Gaffey Shannon S. Sullivan Manisha Witmans Lourdes M. DelRosso Mary Anne Tablizo |
| author_sort | Christopher Harner |
| collection | DOAJ |
| description | Rett syndrome (RTT) is an X-linked neurodevelopmental disorder marked by neurological regression, autonomic dysfunction, seizures, and significant sleep and breathing abnormalities. About 80% of affected individuals, especially young children, experience sleep disturbances such as insomnia, sleep-disordered breathing, nocturnal vocalizations, bruxism, and seizures. Breathing irregularities during sleep—like apnea, alternating hyperventilation, and hypoventilation—are common, with both obstructive and central sleep apnea identified through polysomnography. This review focuses on the prevalent sleep disorders in children with Rett syndrome and highlights current recommendations for the management of sleep disorders. |
| format | Article |
| id | doaj-art-7d9879b0e168409d93f58d557a66bdfa |
| institution | Kabale University |
| issn | 2227-9067 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj-art-7d9879b0e168409d93f58d557a66bdfa2025-08-20T03:58:30ZengMDPI AGChildren2227-90672025-06-0112786910.3390/children12070869Sleep Disorders in Children with Rett SyndromeChristopher Harner0Thomas A. Gaffey1Shannon S. Sullivan2Manisha Witmans3Lourdes M. DelRosso4Mary Anne Tablizo5College of Science, California State University, Turlock, CA 95382, USADepartment of Psychology, University of Notre Dame, Notre Dame, IN 46556, USADivision of Pediatric Pulmonology and Sleep Medicine, Department of Pediatrics, School of Medicine Stanford, Stanford University, Lucile Packard Children’s Hospital, Stanford, CA 94305, USADivision of Pulmonology, Department of Pediatrics, University of Alberta, Edmonton, AB T6G 2R3, CanadaDivision of Sleep Medicine, Department of Internal Medicine, UCSF, Fresno, CA 93701, USADivision of Pediatric Pulmonology and Sleep Medicine, Department of Pediatrics, School of Medicine Stanford, Stanford University, Lucile Packard Children’s Hospital, Stanford, CA 94305, USARett syndrome (RTT) is an X-linked neurodevelopmental disorder marked by neurological regression, autonomic dysfunction, seizures, and significant sleep and breathing abnormalities. About 80% of affected individuals, especially young children, experience sleep disturbances such as insomnia, sleep-disordered breathing, nocturnal vocalizations, bruxism, and seizures. Breathing irregularities during sleep—like apnea, alternating hyperventilation, and hypoventilation—are common, with both obstructive and central sleep apnea identified through polysomnography. This review focuses on the prevalent sleep disorders in children with Rett syndrome and highlights current recommendations for the management of sleep disorders.https://www.mdpi.com/2227-9067/12/7/869Rett syndromeneurodevelopmental disordersleep disorder |
| spellingShingle | Christopher Harner Thomas A. Gaffey Shannon S. Sullivan Manisha Witmans Lourdes M. DelRosso Mary Anne Tablizo Sleep Disorders in Children with Rett Syndrome Children Rett syndrome neurodevelopmental disorder sleep disorder |
| title | Sleep Disorders in Children with Rett Syndrome |
| title_full | Sleep Disorders in Children with Rett Syndrome |
| title_fullStr | Sleep Disorders in Children with Rett Syndrome |
| title_full_unstemmed | Sleep Disorders in Children with Rett Syndrome |
| title_short | Sleep Disorders in Children with Rett Syndrome |
| title_sort | sleep disorders in children with rett syndrome |
| topic | Rett syndrome neurodevelopmental disorder sleep disorder |
| url | https://www.mdpi.com/2227-9067/12/7/869 |
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