PKN2 enhances the immunosuppressive activity of polymorphonuclear myeloid-derived suppressor cells in esophageal carcinoma by mediating fatty acid oxidation

PKN2 enhances the immunosuppressive activity of polymorphonuclear myeloid-derived suppressor cells in esophageal carcinoma by mediating fatty acid oxidation

Abstract Background Myeloid-derived suppressor cells (MDSCs) in tumor microenvironment reduce the efficacy of immunotherapy. PKN2 plays a role in colon cancer, but its function in esophageal cancer (EC) remains unclear. This study investigated PKN2 expression in MDSCs derived from EC tissues and det...

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Bibliographic Details
Main Authors: Xiao Fu, GuoQing Zhang, ZhiChao Hou, TingTing Fu, GuangHui Cui
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Molecular Medicine
Subjects:
Myeloid-derived suppressor cells
PKN2
Fatty acid oxidation
Organoid
Immunosuppressive activity
Online Access:https://doi.org/10.1186/s10020-025-01132-6
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https://doi.org/10.1186/s10020-025-01132-6

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