Mendelian randomization analysis of blood metabolites and immune cell mediators in relation to GVHD and relapse

Mendelian randomization analysis of blood metabolites and immune cell mediators in relation to GVHD and relapse

Abstract Background Graft-versus-host disease (GVHD) and relapse are major complications following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Metabolites play crucial roles in immune regulation, but their causal relationships with GVHD and relapse remain unclear. Methods We util...

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Main Authors: Xinghao Yu, Yiyin Chen, Lei Lei, Pengfei Li, Dandan Lin, Ying Shen, Chang Hou, Jia Chen, Yi Fan, Yi Jin, Huimin Lu, Depei Wu, Yang Xu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Medicine
Subjects:
Allogeneic hematopoietic cell transplantation
Graft-versus-host disease
Metabolite
Immune cell
Mediation
Mendelian randomization
Online Access:https://doi.org/10.1186/s12916-025-04026-w
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