Cervical screening using HPV-DNA cytology in a low-income setting: an audit within a socio-economically deprived rural community in the Philippines
# Background Cervical cancer (CC) is the second leading cause of cancer among women in the Philippines, mainly caused by a persistent human papillomavirus infection (HPV). We aimed to determine the prevalence of HPV and compare screening methods within a socio-economically deprived rural community...
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| Format: | Article |
| Language: | English |
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Inishmore Laser Scientific Publishing Ltd
2023-08-01
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| Series: | Journal of Global Health Reports |
| Online Access: | https://doi.org/10.29392/001c.83912 |
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| _version_ | 1849335103845564416 |
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| author | Elena Harty Samantha Carr Zelda Doyle Charlotte Hespe |
| author_facet | Elena Harty Samantha Carr Zelda Doyle Charlotte Hespe |
| author_sort | Elena Harty |
| collection | DOAJ |
| description | # Background
Cervical cancer (CC) is the second leading cause of cancer among women in the Philippines, mainly caused by a persistent human papillomavirus infection (HPV). We aimed to determine the prevalence of HPV and compare screening methods within a socio-economically deprived rural community in the Philippines.
# Methods
We conducted a retrospective audit of the medical records of 872 women from the free Women's clinic in a regional Philippines community over the period, 2013-2019. All participants were screened for CC using the VIA/VILI method, with only 284 women tested for HPV using the HPV-polymerase chain reaction (HPV-PCR) method. For the 284, we compared their HPV-PCR and VIA/VILI results. Data was de-identified and descriptively analysed.
# Results
Thirteen different HPV subtypes, all oncogenic, exist in the community. HPV was detected in 32 (11%) of the 284 women tested. Of note, 28 patients who had an oncogenic HPV infection had a normal VIA/VILI inspection result. The bivalent vaccine protects only 6% of the HPV-positive cases in the clinic.
# Conclusions
This study suggests HPV-PCR testing is superior at detecting HPV before cervical changes occur. The different oncogenic HPV strains reflect the low coverage of the bivalent HPV vaccination in the community -- a key area for practice and policy reforms. Further studies on the prevalence of oncogenic HPV strains will be vital in designing suitable preventive care programs for CC. |
| format | Article |
| id | doaj-art-7d871802dedf45d5a47744fa1b34fa06 |
| institution | Kabale University |
| issn | 2399-1623 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | Inishmore Laser Scientific Publishing Ltd |
| record_format | Article |
| series | Journal of Global Health Reports |
| spelling | doaj-art-7d871802dedf45d5a47744fa1b34fa062025-08-20T03:45:24ZengInishmore Laser Scientific Publishing LtdJournal of Global Health Reports2399-16232023-08-01710.29392/001c.83912Cervical screening using HPV-DNA cytology in a low-income setting: an audit within a socio-economically deprived rural community in the PhilippinesElena HartySamantha CarrZelda DoyleCharlotte Hespe# Background Cervical cancer (CC) is the second leading cause of cancer among women in the Philippines, mainly caused by a persistent human papillomavirus infection (HPV). We aimed to determine the prevalence of HPV and compare screening methods within a socio-economically deprived rural community in the Philippines. # Methods We conducted a retrospective audit of the medical records of 872 women from the free Women's clinic in a regional Philippines community over the period, 2013-2019. All participants were screened for CC using the VIA/VILI method, with only 284 women tested for HPV using the HPV-polymerase chain reaction (HPV-PCR) method. For the 284, we compared their HPV-PCR and VIA/VILI results. Data was de-identified and descriptively analysed. # Results Thirteen different HPV subtypes, all oncogenic, exist in the community. HPV was detected in 32 (11%) of the 284 women tested. Of note, 28 patients who had an oncogenic HPV infection had a normal VIA/VILI inspection result. The bivalent vaccine protects only 6% of the HPV-positive cases in the clinic. # Conclusions This study suggests HPV-PCR testing is superior at detecting HPV before cervical changes occur. The different oncogenic HPV strains reflect the low coverage of the bivalent HPV vaccination in the community -- a key area for practice and policy reforms. Further studies on the prevalence of oncogenic HPV strains will be vital in designing suitable preventive care programs for CC.https://doi.org/10.29392/001c.83912 |
| spellingShingle | Elena Harty Samantha Carr Zelda Doyle Charlotte Hespe Cervical screening using HPV-DNA cytology in a low-income setting: an audit within a socio-economically deprived rural community in the Philippines Journal of Global Health Reports |
| title | Cervical screening using HPV-DNA cytology in a low-income setting: an audit within a socio-economically deprived rural community in the Philippines |
| title_full | Cervical screening using HPV-DNA cytology in a low-income setting: an audit within a socio-economically deprived rural community in the Philippines |
| title_fullStr | Cervical screening using HPV-DNA cytology in a low-income setting: an audit within a socio-economically deprived rural community in the Philippines |
| title_full_unstemmed | Cervical screening using HPV-DNA cytology in a low-income setting: an audit within a socio-economically deprived rural community in the Philippines |
| title_short | Cervical screening using HPV-DNA cytology in a low-income setting: an audit within a socio-economically deprived rural community in the Philippines |
| title_sort | cervical screening using hpv dna cytology in a low income setting an audit within a socio economically deprived rural community in the philippines |
| url | https://doi.org/10.29392/001c.83912 |
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