Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis.

Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis.

Mammalian Hedgehog (HH) signalling pathway plays an essential role in tissue homeostasis and its deregulation is linked to rheumatological disorders. UBR5 is the mammalian homologue of the E3 ubiquitin-protein ligase Hyd, a negative regulator of the Hh-pathway in Drosophila. To investigate a possibl...

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Main Authors: David Mellis, Katherine A Staines, Silvia Peluso, Ioanna Ch Georgiou, Natalie Dora, Malgorzata Kubiak, Rob Van't Hof, Michela Grillo, Colin Farquharson, Elaine Kinsella, Anna Thornburn, Stuart H Ralston, Donald M Salter, Natalia A Riobo-Del Galdo, Robert E Hill, Mark Ditzel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-04-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009275
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