Development of a core patient-centred outcome set for adults living with obesity: a modified delphi-based international consensusResearch in context
Summary: Background: Obesity is a chronic disease linked to over 200 health conditions, reduced quality of life, and increased mortality. Despite the availability of multimodal treatments, there is a lack of standardised, patient-centred outcome measures to effectively assess and improve clinical c...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
|
| Series: | EClinicalMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589537025003542 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849229244622700544 |
|---|---|
| author | Teferi Mekonnen Leanne Staniford Spencer Connell Zofia Das-Gupta Umanga DeSilva Yasmine Saoud Isabel Miller Mohapradeep Mohan Simon Nienhuijs Megha Poddar Vaishali Chetan Deshmukh Marli Conradie-Smit Soo Huat Teoh Sanjeev Sockalingam Emilia Huvinen Paolo Sbraccia Ronald Liem Michael Vallis Kenneth Clare Tracy Zvenyach Karen Coulman Marianela Aguirre Ackermann Verónica Vázquez-Velázquez Yudith Preiss Contreras Josep Vidal Agbo Urudinachi María Fernanda Tejeda-Muñoz Ian Patton T Alafia Samuels Morgan Emile Gabriel Salmon Leguede Georgia Rigas Ximena Ramos Salas Michael Crotty Bruno Halpern Daniel Bessesen Laura Pizzi Omniyat Mohammed Al Hajeri Arya M. Sharma |
| author_facet | Teferi Mekonnen Leanne Staniford Spencer Connell Zofia Das-Gupta Umanga DeSilva Yasmine Saoud Isabel Miller Mohapradeep Mohan Simon Nienhuijs Megha Poddar Vaishali Chetan Deshmukh Marli Conradie-Smit Soo Huat Teoh Sanjeev Sockalingam Emilia Huvinen Paolo Sbraccia Ronald Liem Michael Vallis Kenneth Clare Tracy Zvenyach Karen Coulman Marianela Aguirre Ackermann Verónica Vázquez-Velázquez Yudith Preiss Contreras Josep Vidal Agbo Urudinachi María Fernanda Tejeda-Muñoz Ian Patton T Alafia Samuels Morgan Emile Gabriel Salmon Leguede Georgia Rigas Ximena Ramos Salas Michael Crotty Bruno Halpern Daniel Bessesen Laura Pizzi Omniyat Mohammed Al Hajeri Arya M. Sharma |
| author_sort | Teferi Mekonnen |
| collection | DOAJ |
| description | Summary: Background: Obesity is a chronic disease linked to over 200 health conditions, reduced quality of life, and increased mortality. Despite the availability of multimodal treatments, there is a lack of standardised, patient-centred outcome measures to effectively assess and improve clinical care. This project aimed to define a core set of standardised outcome measures for adults with obesity, incorporating both patient-reported and clinician-reported outcomes. Additional objectives included determining the optimal measurement frequency and identifying case-mix variables essential for risk adjustment. Methods: The International Consortium for Health Outcomes Measurement (ICHOM) established the Obesity Working Group (OWG), composed of 29 international experts and individuals living with obesity. Members were selected based on their expertise in obesity care and research and represented 21 countries. The development process, conducted from May 2023 to July 2024, began with a kick-off meeting to define scope, followed by eight virtual meetings. A comprehensive literature review informed the identification of relevant clinical outcomes, patient-reported outcomes, treatment-related complications, and case-mix variables. A three-round Delphi process was used to reach consensus on key outcomes and follow-up intervals. Outcomes were included in the final set if at least 80% of OWG members rated them between 7 and 9 on a 9-point scale. Validation was conducted through surveys with 95 patients and 106 healthcare professionals from fields such as dietetics, obesity medicine, and general practice. Findings: The OWG developed a standardised set of 20 outcome measures, comprising 17 core measures and 3 population-specific measures. These span domains including physical health, psychosocial well-being, health behaviours, body functioning, and adverse events. Specific measures were also developed for bariatric surgery and female reproductive health (both pregnant and non-pregnant individuals). Key case-mix factors and appropriate follow-up periods were defined to support global consistency in reporting. Interpretation: Adoption of this standardised outcome set enables clinicians, patients, and stakeholders to identify care gaps, monitor outcomes, and evaluate the quality of obesity care against global benchmarks. Implementation can support the creation of a robust international data resource to guide research, inform clinical practice, and shape policy and guidelines for adult obesity treatment. Limitations include limited geographical diversity in validation surveys, the exclusion of internalised weight bias due to a lack of validated measurement tools, and limited applicability to individuals with obesity and multiple comorbidities. Funding: Novo Nordisk, Eli Lilly, and Boehringer Ingelheim International GmbH. |
| format | Article |
| id | doaj-art-7d792ab801aa42ecb1d4c642abb3f230 |
| institution | Kabale University |
| issn | 2589-5370 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EClinicalMedicine |
| spelling | doaj-art-7d792ab801aa42ecb1d4c642abb3f2302025-08-22T04:57:12ZengElsevierEClinicalMedicine2589-53702025-09-018710342210.1016/j.eclinm.2025.103422Development of a core patient-centred outcome set for adults living with obesity: a modified delphi-based international consensusResearch in contextTeferi Mekonnen0Leanne Staniford1Spencer Connell2Zofia Das-Gupta3Umanga DeSilva4Yasmine Saoud5Isabel Miller6Mohapradeep Mohan7Simon Nienhuijs8Megha Poddar9Vaishali Chetan Deshmukh10Marli Conradie-Smit11Soo Huat Teoh12Sanjeev Sockalingam13Emilia Huvinen14Paolo Sbraccia15Ronald Liem16Michael Vallis17Kenneth Clare18Tracy Zvenyach19Karen Coulman20Marianela Aguirre Ackermann21Verónica Vázquez-Velázquez22Yudith Preiss Contreras23Josep Vidal24Agbo Urudinachi25María Fernanda Tejeda-Muñoz26Ian Patton27T Alafia Samuels28Morgan Emile Gabriel Salmon Leguede29Georgia Rigas30Ximena Ramos Salas31Michael Crotty32Bruno Halpern33Daniel Bessesen34Laura Pizzi35Omniyat Mohammed Al Hajeri36Arya M. Sharma37Nordic Institute of Dental Materials and Norwegian Institute of Public Health, NorwayLancaster University, EnglandICHOM, USAICHOM, USAICHOM, USAICHOM, USAICHOM, USAICHOM, USACatharina Hospital Eindhoven, Eindhoven, NetherlandsMcMaster University, Ontario, CanadaDeenanath Mangeshkar Hospital and Deshmukh Clinic and Research Centre, Pune, IndiaDivision of Endocrinology, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South AfricaUniversiti Sains Malaysia, Pulau Pinang, MalaysiaCentre for Addiction and Mental Health, University of Toronto, Toronto, CanadaDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, FinlandDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyGroene Hart Ziekenhuis in Gouda, Netherlands and Nederlandse Obesitas Kliniek in the Hague and Gouda, NetherlandsFamily Medicine, Dalhousie University, Halifax, CanadaLeeds Beckett University, Leeds, EnglandObesity Action Coalition, United StatesBristol Medical School - Department of Population Health Sciences, University of Bristol, EnglandCIEN Foundation, Integral Center for Obesity and Diabetes, ArgentinaInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Obesidades, Mexico City, MexicoClínica MEDS, Centro Médico NOVAMED, Santiago, ChileDepartment of Endocrinology, Institut d‘Investigacions Biomédiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, SpainDepartment of Community Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki Ebonyi State, NigeriaObesidades, Mexico City, MexicoObesity Canada, Edmonton, Alberta, CanadaCaribbean Institute for Health Research, University of the West Indies, Kingston, JamaicaAlianza Hispana de Personas con Obesidad, Copenhagen, DenmarkSt George & Sutherland Clinical School, University of New South Wales-Medicine, Sydney, AustraliaReplica Communications, SwedenIrish College of GPs, IrelandObesity Centre, Hospital 9 de Julho, São Paulo, BrazilThe Obesity Society, USAThe International Society for Pharmacoeconomics and Outcomes Research (ISPOR), USAAbu Dhabi Public Health Center, Abu Dhabi, United Arab EmiratesDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada; Corresponding author.Summary: Background: Obesity is a chronic disease linked to over 200 health conditions, reduced quality of life, and increased mortality. Despite the availability of multimodal treatments, there is a lack of standardised, patient-centred outcome measures to effectively assess and improve clinical care. This project aimed to define a core set of standardised outcome measures for adults with obesity, incorporating both patient-reported and clinician-reported outcomes. Additional objectives included determining the optimal measurement frequency and identifying case-mix variables essential for risk adjustment. Methods: The International Consortium for Health Outcomes Measurement (ICHOM) established the Obesity Working Group (OWG), composed of 29 international experts and individuals living with obesity. Members were selected based on their expertise in obesity care and research and represented 21 countries. The development process, conducted from May 2023 to July 2024, began with a kick-off meeting to define scope, followed by eight virtual meetings. A comprehensive literature review informed the identification of relevant clinical outcomes, patient-reported outcomes, treatment-related complications, and case-mix variables. A three-round Delphi process was used to reach consensus on key outcomes and follow-up intervals. Outcomes were included in the final set if at least 80% of OWG members rated them between 7 and 9 on a 9-point scale. Validation was conducted through surveys with 95 patients and 106 healthcare professionals from fields such as dietetics, obesity medicine, and general practice. Findings: The OWG developed a standardised set of 20 outcome measures, comprising 17 core measures and 3 population-specific measures. These span domains including physical health, psychosocial well-being, health behaviours, body functioning, and adverse events. Specific measures were also developed for bariatric surgery and female reproductive health (both pregnant and non-pregnant individuals). Key case-mix factors and appropriate follow-up periods were defined to support global consistency in reporting. Interpretation: Adoption of this standardised outcome set enables clinicians, patients, and stakeholders to identify care gaps, monitor outcomes, and evaluate the quality of obesity care against global benchmarks. Implementation can support the creation of a robust international data resource to guide research, inform clinical practice, and shape policy and guidelines for adult obesity treatment. Limitations include limited geographical diversity in validation surveys, the exclusion of internalised weight bias due to a lack of validated measurement tools, and limited applicability to individuals with obesity and multiple comorbidities. Funding: Novo Nordisk, Eli Lilly, and Boehringer Ingelheim International GmbH.http://www.sciencedirect.com/science/article/pii/S2589537025003542ICHOMAdult obesityClinical practiceOutcome measuresPatient-centred outcomes |
| spellingShingle | Teferi Mekonnen Leanne Staniford Spencer Connell Zofia Das-Gupta Umanga DeSilva Yasmine Saoud Isabel Miller Mohapradeep Mohan Simon Nienhuijs Megha Poddar Vaishali Chetan Deshmukh Marli Conradie-Smit Soo Huat Teoh Sanjeev Sockalingam Emilia Huvinen Paolo Sbraccia Ronald Liem Michael Vallis Kenneth Clare Tracy Zvenyach Karen Coulman Marianela Aguirre Ackermann Verónica Vázquez-Velázquez Yudith Preiss Contreras Josep Vidal Agbo Urudinachi María Fernanda Tejeda-Muñoz Ian Patton T Alafia Samuels Morgan Emile Gabriel Salmon Leguede Georgia Rigas Ximena Ramos Salas Michael Crotty Bruno Halpern Daniel Bessesen Laura Pizzi Omniyat Mohammed Al Hajeri Arya M. Sharma Development of a core patient-centred outcome set for adults living with obesity: a modified delphi-based international consensusResearch in context EClinicalMedicine ICHOM Adult obesity Clinical practice Outcome measures Patient-centred outcomes |
| title | Development of a core patient-centred outcome set for adults living with obesity: a modified delphi-based international consensusResearch in context |
| title_full | Development of a core patient-centred outcome set for adults living with obesity: a modified delphi-based international consensusResearch in context |
| title_fullStr | Development of a core patient-centred outcome set for adults living with obesity: a modified delphi-based international consensusResearch in context |
| title_full_unstemmed | Development of a core patient-centred outcome set for adults living with obesity: a modified delphi-based international consensusResearch in context |
| title_short | Development of a core patient-centred outcome set for adults living with obesity: a modified delphi-based international consensusResearch in context |
| title_sort | development of a core patient centred outcome set for adults living with obesity a modified delphi based international consensusresearch in context |
| topic | ICHOM Adult obesity Clinical practice Outcome measures Patient-centred outcomes |
| url | http://www.sciencedirect.com/science/article/pii/S2589537025003542 |
| work_keys_str_mv | AT teferimekonnen developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT leannestaniford developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT spencerconnell developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT zofiadasgupta developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT umangadesilva developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT yasminesaoud developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT isabelmiller developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT mohapradeepmohan developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT simonnienhuijs developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT meghapoddar developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT vaishalichetandeshmukh developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT marliconradiesmit developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT soohuatteoh developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT sanjeevsockalingam developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT emiliahuvinen developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT paolosbraccia developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT ronaldliem developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT michaelvallis developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT kennethclare developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT tracyzvenyach developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT karencoulman developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT marianelaaguirreackermann developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT veronicavazquezvelazquez developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT yudithpreisscontreras developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT josepvidal developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT agbourudinachi developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT mariafernandatejedamunoz developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT ianpatton developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT talafiasamuels developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT morganemilegabrielsalmonleguede developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT georgiarigas developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT ximenaramossalas developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT michaelcrotty developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT brunohalpern developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT danielbessesen developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT laurapizzi developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT omniyatmohammedalhajeri developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext AT aryamsharma developmentofacorepatientcentredoutcomesetforadultslivingwithobesityamodifieddelphibasedinternationalconsensusresearchincontext |