YAP K236 acetylation facilitates its nucleic export and deprived the protection against cardiac hypertrophy in mice

YAP K236 acetylation facilitates its nucleic export and deprived the protection against cardiac hypertrophy in mice

The subcellular localization of Yes-associated protein (YAP) is dynamically regulated by post-transcriptional modifications, critically influencing cardiac function. Despite its significance, the precise mechanism controlling YAP nuclear sequestration and its role in cardiac hypertrophy remain poorl...

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Bibliographic Details
Main Authors: Panxia Wang, Luping Wang, Cui Liu, Yuehuai Hu, Guodong Feng, Zuqian Lian, Jing Lu, Ping He, Hexin Cai, Xiaohui Liang, Peiqing Liu, Xiaoqian Wu
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Pharmacological Research
Subjects:
Cardiac hypertrophy
YAP
K236 residues
Acetylation
SIRT6
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824005188
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