Targeting PFKFB3 to restore glucose metabolism in acute pancreatitis via nanovesicle delivery

Targeting PFKFB3 to restore glucose metabolism in acute pancreatitis via nanovesicle delivery

Abstract Background Acute pancreatitis (AP) is a severe inflammatory disease frequently accompanied by disturbances in glucose metabolism, which further complicate the disease prognosis. This study aims to explore the role of PFKFB3, a key glycolytic enzyme, in regulating glucose metabolism in AP an...

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Bibliographic Details
Main Authors: Hai Jiang, Zhipeng Xu, Qi Song, Junjie Tao, Jia Liu, Qiang Wang, Huaisheng Zhang, Heng Zhu, Qiliang Li, Lei Li
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Molecular Medicine
Subjects:
Acute pancreatitis
Glucose metabolism disorder
PFKFB3 inhibitor
Nanovesicles
Single-cell RNA sequencing
Machine learning
Online Access:https://doi.org/10.1186/s10020-025-01261-y
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