Prognostic value of albumin-bilirubin grade in patients with cholangiocarcinoma: a systematic review and meta-analysis
Abstract Background Cholangiocarcinoma (CCA) is a type of cancer that develops in the biliary tract. CCA accounts for 10% of primary hepatic cancers and is characterized by its aggressive nature and poor prognosis. This systematic review and meta-analysis aims to assess the prognostic value of the n...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12876-025-03596-6 |
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| author | Mahyaar Omouri-Kharashtomi Seyedeh Yasaman Alemohammad Negin Moazed Inas Afzali Nezhad Hamed Ghoshouni |
| author_facet | Mahyaar Omouri-Kharashtomi Seyedeh Yasaman Alemohammad Negin Moazed Inas Afzali Nezhad Hamed Ghoshouni |
| author_sort | Mahyaar Omouri-Kharashtomi |
| collection | DOAJ |
| description | Abstract Background Cholangiocarcinoma (CCA) is a type of cancer that develops in the biliary tract. CCA accounts for 10% of primary hepatic cancers and is characterized by its aggressive nature and poor prognosis. This systematic review and meta-analysis aims to assess the prognostic value of the novel hepatic function assessment measure known as albumin-bilirubin (ALBI) grade in patients with CCA. Method A comprehensive search was conducted on PubMed, Web of Science, Embase, and Scopus databases until August 11, 2023. Studies examining the prognostic impact of ALBI grade in patients with CCA were included. The prognostic effect was evaluated using hazard ratio (HR) with 95% confidence intervals (CI). The quality of the included studies was assessed using the Newcastle–Ottawa Scale (NOS). The final meta-analysis was performed using R version 4.3.1. Results The final meta-analysis included 13 studies with 3,434 patients. In univariate analysis (HR = 1.90, 95% CI: 1.65–2.19, P < 0.01) and multivariate analysis (HR = 1.88, 95% CI: 1.41–2.52, P < 0.01), higher ALBI grade was associated with lower overall survival (OS) in patients with intrahepatic CCA (ICCA). Higher ALBI grade was also correlated with decreased recurrence-free survival (RFS), with an HR of 1.63 (95% CI: 1.36–1.97, P < 0.01). Subgroup analysis of different ALBI grade comparisons showed consistent findings with our pooled data. Conclusion A high ALBI grade indicates poor OS and RFS in patients with CCA especially intrahepatic type. ALBI should be considered a reliable and clinically useful prognostic indicator. Registration PROSPERO ID: CRD42022379877 |
| format | Article |
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| institution | Kabale University |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj-art-7d7356fd489a4c7e933ade3b05be5e742025-01-19T12:25:41ZengBMCBMC Gastroenterology1471-230X2025-01-0125111310.1186/s12876-025-03596-6Prognostic value of albumin-bilirubin grade in patients with cholangiocarcinoma: a systematic review and meta-analysisMahyaar Omouri-Kharashtomi0Seyedeh Yasaman Alemohammad1Negin Moazed2Inas Afzali Nezhad3Hamed Ghoshouni4Student Research Committee, Ahvaz Jundishapour University of Medical SciencesFlorida International UniversityStudent Research Committee, Ahvaz Jundishapour University of Medical SciencesStudent Research Committee, Ahvaz Jundishapour University of Medical SciencesCardiovascular Epidemiology Research Center, Rajaie Cardiovascular InstituteAbstract Background Cholangiocarcinoma (CCA) is a type of cancer that develops in the biliary tract. CCA accounts for 10% of primary hepatic cancers and is characterized by its aggressive nature and poor prognosis. This systematic review and meta-analysis aims to assess the prognostic value of the novel hepatic function assessment measure known as albumin-bilirubin (ALBI) grade in patients with CCA. Method A comprehensive search was conducted on PubMed, Web of Science, Embase, and Scopus databases until August 11, 2023. Studies examining the prognostic impact of ALBI grade in patients with CCA were included. The prognostic effect was evaluated using hazard ratio (HR) with 95% confidence intervals (CI). The quality of the included studies was assessed using the Newcastle–Ottawa Scale (NOS). The final meta-analysis was performed using R version 4.3.1. Results The final meta-analysis included 13 studies with 3,434 patients. In univariate analysis (HR = 1.90, 95% CI: 1.65–2.19, P < 0.01) and multivariate analysis (HR = 1.88, 95% CI: 1.41–2.52, P < 0.01), higher ALBI grade was associated with lower overall survival (OS) in patients with intrahepatic CCA (ICCA). Higher ALBI grade was also correlated with decreased recurrence-free survival (RFS), with an HR of 1.63 (95% CI: 1.36–1.97, P < 0.01). Subgroup analysis of different ALBI grade comparisons showed consistent findings with our pooled data. Conclusion A high ALBI grade indicates poor OS and RFS in patients with CCA especially intrahepatic type. ALBI should be considered a reliable and clinically useful prognostic indicator. Registration PROSPERO ID: CRD42022379877https://doi.org/10.1186/s12876-025-03596-6Albumin-bilirubin gradeALBI gradeCholangiocarcinomaIntrahepatic cholangiocarcinomaPrognosisPrognostic factor |
| spellingShingle | Mahyaar Omouri-Kharashtomi Seyedeh Yasaman Alemohammad Negin Moazed Inas Afzali Nezhad Hamed Ghoshouni Prognostic value of albumin-bilirubin grade in patients with cholangiocarcinoma: a systematic review and meta-analysis BMC Gastroenterology Albumin-bilirubin grade ALBI grade Cholangiocarcinoma Intrahepatic cholangiocarcinoma Prognosis Prognostic factor |
| title | Prognostic value of albumin-bilirubin grade in patients with cholangiocarcinoma: a systematic review and meta-analysis |
| title_full | Prognostic value of albumin-bilirubin grade in patients with cholangiocarcinoma: a systematic review and meta-analysis |
| title_fullStr | Prognostic value of albumin-bilirubin grade in patients with cholangiocarcinoma: a systematic review and meta-analysis |
| title_full_unstemmed | Prognostic value of albumin-bilirubin grade in patients with cholangiocarcinoma: a systematic review and meta-analysis |
| title_short | Prognostic value of albumin-bilirubin grade in patients with cholangiocarcinoma: a systematic review and meta-analysis |
| title_sort | prognostic value of albumin bilirubin grade in patients with cholangiocarcinoma a systematic review and meta analysis |
| topic | Albumin-bilirubin grade ALBI grade Cholangiocarcinoma Intrahepatic cholangiocarcinoma Prognosis Prognostic factor |
| url | https://doi.org/10.1186/s12876-025-03596-6 |
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