Genetic Downregulation of GABA<sub>B</sub> Receptors from Oligodendrocyte Precursor Cells Protects Against Demyelination in the Mouse Spinal Cord

Genetic Downregulation of GABA<sub>B</sub> Receptors from Oligodendrocyte Precursor Cells Protects Against Demyelination in the Mouse Spinal Cord

GABAergic signaling and GABA<sub>B</sub> receptors play crucial roles in regulating the physiology of oligodendrocyte-lineage cells, including their proliferation, differentiation, and myelination. Therefore, they are promising targets for studying how spinal oligodendrocyte precursor ce...

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Bibliographic Details
Main Authors: Davide Gobbo, Phillip Rieder, Li-Pao Fang, Emeline Buttigieg, Moritz Schablowski, Elisa Damo, Nathalie Bosche, Eleonora Dallorto, Pascal May, Xianshu Bai, Frank Kirchhoff, Anja Scheller
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Cells
Subjects:
spinal cord
GABA<sub>B</sub> receptors
oligodendrocyte precursor cells
demyelination
cuprizone
Online Access:https://www.mdpi.com/2073-4409/13/23/2014
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