Synthesis of heterocycle based carboxymethyl cellulose conjugates as novel anticancer agents targeting HCT116, MCF7, PC3 and A549 cells
Abstract Toward developing anticancer agents, heterocycle-based carboxymethyl cellulose conjugates have been synthesized. 2-Cyano-N′-(aryl/heteroarylethylidene)acetohydrazides and ethyl 2-cyano-3-(heteryl)acrylates were utilized as precursors for the synthesis of pyridine-based compounds. The chemic...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-08-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-14146-1 |
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| author | Reham A. Mohamed-Ezzat Zeinab A. Elshahid Shaimaa A. Gouhar Sawsan Dacrory |
| author_facet | Reham A. Mohamed-Ezzat Zeinab A. Elshahid Shaimaa A. Gouhar Sawsan Dacrory |
| author_sort | Reham A. Mohamed-Ezzat |
| collection | DOAJ |
| description | Abstract Toward developing anticancer agents, heterocycle-based carboxymethyl cellulose conjugates have been synthesized. 2-Cyano-N′-(aryl/heteroarylethylidene)acetohydrazides and ethyl 2-cyano-3-(heteryl)acrylates were utilized as precursors for the synthesis of pyridine-based compounds. The chemical structures of the synthesized derivatives were characterized using various spectroscopic techniques, including 1H-, 13C-NMR, Fourier transform infrared spectroscopy (FTIR), as well as scanning electron microscopy (SEM).The anticancer effects of compounds on HCT-116, MCF-7, PC3 and A549 cancer cell lines were investigated and their cytotoxicity against RPE-1 normal cells was estimated to determine their safety. Compounds 4b and 7c exhibit high selectivity toward cancer cells while maintaining a strong safety margin for normal cells. The results demonstrated that the novel heterocycle-based carboxymethyl cellulose conjugates are promising and can be further evaluated as a potential therapeutic agent. |
| format | Article |
| id | doaj-art-7d657154f5124ebc92c5477e2f7229fe |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-7d657154f5124ebc92c5477e2f7229fe2025-08-20T03:42:53ZengNature PortfolioScientific Reports2045-23222025-08-0115111410.1038/s41598-025-14146-1Synthesis of heterocycle based carboxymethyl cellulose conjugates as novel anticancer agents targeting HCT116, MCF7, PC3 and A549 cellsReham A. Mohamed-Ezzat0Zeinab A. Elshahid1Shaimaa A. Gouhar2Sawsan Dacrory3Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research CentreChemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research CentreMedical Biochemistry Department, Medical Research and Clinical Studies Institute, National Research CentreCellulose and Paper Department, National Research CentreAbstract Toward developing anticancer agents, heterocycle-based carboxymethyl cellulose conjugates have been synthesized. 2-Cyano-N′-(aryl/heteroarylethylidene)acetohydrazides and ethyl 2-cyano-3-(heteryl)acrylates were utilized as precursors for the synthesis of pyridine-based compounds. The chemical structures of the synthesized derivatives were characterized using various spectroscopic techniques, including 1H-, 13C-NMR, Fourier transform infrared spectroscopy (FTIR), as well as scanning electron microscopy (SEM).The anticancer effects of compounds on HCT-116, MCF-7, PC3 and A549 cancer cell lines were investigated and their cytotoxicity against RPE-1 normal cells was estimated to determine their safety. Compounds 4b and 7c exhibit high selectivity toward cancer cells while maintaining a strong safety margin for normal cells. The results demonstrated that the novel heterocycle-based carboxymethyl cellulose conjugates are promising and can be further evaluated as a potential therapeutic agent.https://doi.org/10.1038/s41598-025-14146-1SynthesisPyridineAnticancerCarboxymethyl cellulose |
| spellingShingle | Reham A. Mohamed-Ezzat Zeinab A. Elshahid Shaimaa A. Gouhar Sawsan Dacrory Synthesis of heterocycle based carboxymethyl cellulose conjugates as novel anticancer agents targeting HCT116, MCF7, PC3 and A549 cells Scientific Reports Synthesis Pyridine Anticancer Carboxymethyl cellulose |
| title | Synthesis of heterocycle based carboxymethyl cellulose conjugates as novel anticancer agents targeting HCT116, MCF7, PC3 and A549 cells |
| title_full | Synthesis of heterocycle based carboxymethyl cellulose conjugates as novel anticancer agents targeting HCT116, MCF7, PC3 and A549 cells |
| title_fullStr | Synthesis of heterocycle based carboxymethyl cellulose conjugates as novel anticancer agents targeting HCT116, MCF7, PC3 and A549 cells |
| title_full_unstemmed | Synthesis of heterocycle based carboxymethyl cellulose conjugates as novel anticancer agents targeting HCT116, MCF7, PC3 and A549 cells |
| title_short | Synthesis of heterocycle based carboxymethyl cellulose conjugates as novel anticancer agents targeting HCT116, MCF7, PC3 and A549 cells |
| title_sort | synthesis of heterocycle based carboxymethyl cellulose conjugates as novel anticancer agents targeting hct116 mcf7 pc3 and a549 cells |
| topic | Synthesis Pyridine Anticancer Carboxymethyl cellulose |
| url | https://doi.org/10.1038/s41598-025-14146-1 |
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