The effect of dexmedetomidine on hemodynamic parameters during neuro-oncological surgery
Introduction. The use of alpha 2-adrenoagonist dexmedetomidine, as an adjuvant for anesthesiological aid in neuro-oncological surgery, allows to create and maintain stable hemodynamics throughout the entire surgical intervention. The observed hemodynamic effects depend on the dose of dexmedetomidine...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2024-08-01
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| Series: | Вестник анестезиологии и реаниматологии |
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| Online Access: | https://www.vair-journal.com/jour/article/view/1033 |
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| author | M. V. Rumiantceva L. M. Tsentsiper A. N. Kondratyev |
| author_facet | M. V. Rumiantceva L. M. Tsentsiper A. N. Kondratyev |
| author_sort | M. V. Rumiantceva |
| collection | DOAJ |
| description | Introduction. The use of alpha 2-adrenoagonist dexmedetomidine, as an adjuvant for anesthesiological aid in neuro-oncological surgery, allows to create and maintain stable hemodynamics throughout the entire surgical intervention. The observed hemodynamic effects depend on the dose of dexmedetomidine.The objective was to evaluate the effect of the highly selective alpha2-adrenoagonist dexmedetomidine on hemodynamic parameters during anesthesia in surgeries for the removal of a brain tumor.Materials and methods. The study included 92 patients operated on for a brain tumor. The division into groups was carried out depending on the dosage of dexmedetomidine and the position on the operating table. In group 1 (n = 58), dexmedetomidine was used, which was administered during the first 30–40 minutes at a rate of 1.4 ± 0.4 mkg/kg/h, and after introductory anesthesia at a maintenance dosage of 0.4 ± 0.2 mkg/kg/h. In group 2 (n = 34), dexmedetomidine was administered during the first 30–40 minutes at a rate of 0.7 ± 0.1 mkg/kg/h, and after induction of anesthesia with a maintenance dosage of 0.2 ± 0.1 mkg/kg/h. Subgroup A – patients operated in a sitting position, subgroup B – patients operated in a lying position.Results. More stable hemodynamics and mild parasympathicotonia were noted at all stages of surgery when dexmedetomidine was used at an initial dose of 0.7 ± 0.1 mkg/kg/h and a maintenance dose of 0.2 ± 0.1 mkg/kg/h. Conclusion. The study revealed that the optimal dosage of dexmedtomidine to achieve a central sympathomodulating effect is 0.7 ± 0.1 mkg/kg/h in the initial stages and 0.2 ± 0.1 mkg/kg/h in the maintenance. |
| format | Article |
| id | doaj-art-7d64420ce9bb4201844b7ebdbbdc85fd |
| institution | Kabale University |
| issn | 2078-5658 2541-8653 |
| language | Russian |
| publishDate | 2024-08-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Вестник анестезиологии и реаниматологии |
| spelling | doaj-art-7d64420ce9bb4201844b7ebdbbdc85fd2025-08-20T03:42:56ZrusNew Terra Publishing HouseВестник анестезиологии и реаниматологии2078-56582541-86532024-08-01214434910.24884/2078-5658-2024-21-4-43-49695The effect of dexmedetomidine on hemodynamic parameters during neuro-oncological surgeryM. V. Rumiantceva0L. M. Tsentsiper1A. N. Kondratyev2Research Laboratory “Neuroprotection and Neurometabolic Disorders”, Polenov Russian Research Neurosurgical Institute, Branch of the Almazov National Medical Research CentrePolenov Russian Research Neurosurgical Institute, branch of the Almazov National Medical Research Centre; Almazov National Medical Research Centre; Saint-Petersburg State Pediatric Medical UniversityPolenov Russian Research Neurosurgical Institute, branch of the Almazov National Medical Research CentreIntroduction. The use of alpha 2-adrenoagonist dexmedetomidine, as an adjuvant for anesthesiological aid in neuro-oncological surgery, allows to create and maintain stable hemodynamics throughout the entire surgical intervention. The observed hemodynamic effects depend on the dose of dexmedetomidine.The objective was to evaluate the effect of the highly selective alpha2-adrenoagonist dexmedetomidine on hemodynamic parameters during anesthesia in surgeries for the removal of a brain tumor.Materials and methods. The study included 92 patients operated on for a brain tumor. The division into groups was carried out depending on the dosage of dexmedetomidine and the position on the operating table. In group 1 (n = 58), dexmedetomidine was used, which was administered during the first 30–40 minutes at a rate of 1.4 ± 0.4 mkg/kg/h, and after introductory anesthesia at a maintenance dosage of 0.4 ± 0.2 mkg/kg/h. In group 2 (n = 34), dexmedetomidine was administered during the first 30–40 minutes at a rate of 0.7 ± 0.1 mkg/kg/h, and after induction of anesthesia with a maintenance dosage of 0.2 ± 0.1 mkg/kg/h. Subgroup A – patients operated in a sitting position, subgroup B – patients operated in a lying position.Results. More stable hemodynamics and mild parasympathicotonia were noted at all stages of surgery when dexmedetomidine was used at an initial dose of 0.7 ± 0.1 mkg/kg/h and a maintenance dose of 0.2 ± 0.1 mkg/kg/h. Conclusion. The study revealed that the optimal dosage of dexmedtomidine to achieve a central sympathomodulating effect is 0.7 ± 0.1 mkg/kg/h in the initial stages and 0.2 ± 0.1 mkg/kg/h in the maintenance.https://www.vair-journal.com/jour/article/view/1033brain tumoranesthesiahemodynamicsalpha2-adrenoagonistdexmedetomidine |
| spellingShingle | M. V. Rumiantceva L. M. Tsentsiper A. N. Kondratyev The effect of dexmedetomidine on hemodynamic parameters during neuro-oncological surgery Вестник анестезиологии и реаниматологии brain tumor anesthesia hemodynamics alpha2-adrenoagonist dexmedetomidine |
| title | The effect of dexmedetomidine on hemodynamic parameters during neuro-oncological surgery |
| title_full | The effect of dexmedetomidine on hemodynamic parameters during neuro-oncological surgery |
| title_fullStr | The effect of dexmedetomidine on hemodynamic parameters during neuro-oncological surgery |
| title_full_unstemmed | The effect of dexmedetomidine on hemodynamic parameters during neuro-oncological surgery |
| title_short | The effect of dexmedetomidine on hemodynamic parameters during neuro-oncological surgery |
| title_sort | effect of dexmedetomidine on hemodynamic parameters during neuro oncological surgery |
| topic | brain tumor anesthesia hemodynamics alpha2-adrenoagonist dexmedetomidine |
| url | https://www.vair-journal.com/jour/article/view/1033 |
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