HIV pre-exposure prophylaxis (PrEP) use among PrEP-eligible men who have sex with men: A systematic review and meta-analysis
Objective: Scaling up pre-exposure prophylaxis (PrEP) is critical to combating the AIDS epidemic, especially among PrEP-eligible men who have sex with men (MSM). This study summarizes the global proportion of PrEP-eligible MSM with PrEP use and highlights the contextual differences in eligibility cr...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971225000979 |
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| author | Yuyan Zhao Huishan Li Yiting Huang Ziwei Zhou Zhuoqian He Bruce Agins Jason J. Ong Huachun Zou Yangyang She Hongbo Jiang |
| author_facet | Yuyan Zhao Huishan Li Yiting Huang Ziwei Zhou Zhuoqian He Bruce Agins Jason J. Ong Huachun Zou Yangyang She Hongbo Jiang |
| author_sort | Yuyan Zhao |
| collection | DOAJ |
| description | Objective: Scaling up pre-exposure prophylaxis (PrEP) is critical to combating the AIDS epidemic, especially among PrEP-eligible men who have sex with men (MSM). This study summarizes the global proportion of PrEP-eligible MSM with PrEP use and highlights the contextual differences in eligibility criteria for PrEP across studies. Methods: A literature search was conducted in four databases in July 2023. We determined the proportion of PrEP-eligible MSM with PrEP use and its 95% confidence interval (CI) using a random-effects meta-analysis. Results: 50 eligible studies involving 96,151 PrEP-eligible MSM were included. The overall pooled estimate of PrEP-eligible MSM with a history of PrEP use and current PrEP use was 19.3% (95% CI 13.9-26.2) and 21.8% (95% CI 17.6-26.7) with β regressions indicating an increasing trend. Subgroup analyses showed lower PrEP use among young MSM, and differences in PrEP use by research year, country income level, policy support and WHO region. Variations in eligibility criteria for PrEP were observed across studies. Conclusions: An overall increase in PrEP use among PrEP-eligible MSM was observed, with differences in PrEP use mainly by age. Emphasis on identifying PrEP-eligible MSM, particularly young MSM and removing financial barriers for effective implementation. Global PrEP criteria should be more standardized and based on the latest science. |
| format | Article |
| id | doaj-art-7d55f95022db4f0690cce2fffcfde278 |
| institution | DOAJ |
| issn | 1201-9712 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj-art-7d55f95022db4f0690cce2fffcfde2782025-08-20T03:09:09ZengElsevierInternational Journal of Infectious Diseases1201-97122025-05-0115410787410.1016/j.ijid.2025.107874HIV pre-exposure prophylaxis (PrEP) use among PrEP-eligible men who have sex with men: A systematic review and meta-analysisYuyan Zhao0Huishan Li1Yiting Huang2Ziwei Zhou3Zhuoqian He4Bruce Agins5Jason J. Ong6Huachun Zou7Yangyang She8Hongbo Jiang9Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, PR ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, PR ChinaDepartment of Medical Statistics, School of Basic Medicine and Public Health, Jinan University, Guangzhou, PR ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, PR China; Department of Medical Statistics, School of Basic Medicine and Public Health, Jinan University, Guangzhou, PR China; Department of Preventive Health Care, The Second People's Hospital of Longgang District, Shenzhen, PR China; HEALTHQUAL, Institute for Global Health Sciences, University of California, San Francisco, California, USA; School of Translational Medicine, Monash University, Melbourne, Australia; School of Public Health, Fudan University, Shanghai, PR China; Department of Stomatology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, PR ChinaHEALTHQUAL, Institute for Global Health Sciences, University of California, San Francisco, California, USASchool of Translational Medicine, Monash University, Melbourne, AustraliaSchool of Public Health, Fudan University, Shanghai, PR ChinaDepartment of Stomatology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, PR China; Corresponding author: Hongbo Jiang, Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510310, China.Objective: Scaling up pre-exposure prophylaxis (PrEP) is critical to combating the AIDS epidemic, especially among PrEP-eligible men who have sex with men (MSM). This study summarizes the global proportion of PrEP-eligible MSM with PrEP use and highlights the contextual differences in eligibility criteria for PrEP across studies. Methods: A literature search was conducted in four databases in July 2023. We determined the proportion of PrEP-eligible MSM with PrEP use and its 95% confidence interval (CI) using a random-effects meta-analysis. Results: 50 eligible studies involving 96,151 PrEP-eligible MSM were included. The overall pooled estimate of PrEP-eligible MSM with a history of PrEP use and current PrEP use was 19.3% (95% CI 13.9-26.2) and 21.8% (95% CI 17.6-26.7) with β regressions indicating an increasing trend. Subgroup analyses showed lower PrEP use among young MSM, and differences in PrEP use by research year, country income level, policy support and WHO region. Variations in eligibility criteria for PrEP were observed across studies. Conclusions: An overall increase in PrEP use among PrEP-eligible MSM was observed, with differences in PrEP use mainly by age. Emphasis on identifying PrEP-eligible MSM, particularly young MSM and removing financial barriers for effective implementation. Global PrEP criteria should be more standardized and based on the latest science.http://www.sciencedirect.com/science/article/pii/S1201971225000979Men who have sex with menHIVPre-exposure prophylaxis (PrEP)PrEP-eligibilitySystematic reviewMeta-analysis |
| spellingShingle | Yuyan Zhao Huishan Li Yiting Huang Ziwei Zhou Zhuoqian He Bruce Agins Jason J. Ong Huachun Zou Yangyang She Hongbo Jiang HIV pre-exposure prophylaxis (PrEP) use among PrEP-eligible men who have sex with men: A systematic review and meta-analysis International Journal of Infectious Diseases Men who have sex with men HIV Pre-exposure prophylaxis (PrEP) PrEP-eligibility Systematic review Meta-analysis |
| title | HIV pre-exposure prophylaxis (PrEP) use among PrEP-eligible men who have sex with men: A systematic review and meta-analysis |
| title_full | HIV pre-exposure prophylaxis (PrEP) use among PrEP-eligible men who have sex with men: A systematic review and meta-analysis |
| title_fullStr | HIV pre-exposure prophylaxis (PrEP) use among PrEP-eligible men who have sex with men: A systematic review and meta-analysis |
| title_full_unstemmed | HIV pre-exposure prophylaxis (PrEP) use among PrEP-eligible men who have sex with men: A systematic review and meta-analysis |
| title_short | HIV pre-exposure prophylaxis (PrEP) use among PrEP-eligible men who have sex with men: A systematic review and meta-analysis |
| title_sort | hiv pre exposure prophylaxis prep use among prep eligible men who have sex with men a systematic review and meta analysis |
| topic | Men who have sex with men HIV Pre-exposure prophylaxis (PrEP) PrEP-eligibility Systematic review Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S1201971225000979 |
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