Association of Triglyceride‐Glucose Index, Triglyceride to High‐Density Lipoprotein Cholesterol Ratio, and Related Parameters With Prehypertension and Hypertension
ABSTRACT The objective of this study was to investigate the association between triglyceride to high‐density lipoprotein cholesterol ratio (TG/HDL‐c), triglyceride‐glucose index (TyG), and related parameters (TyG‐BMI, TyG‐WC) with prehypertension and hypertension over 45 years old. According to the...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | The Journal of Clinical Hypertension |
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| Online Access: | https://doi.org/10.1111/jch.14926 |
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| author | Shijie Yang Yuqing Zhang Zhanyang Zhou Xiaochun Duan |
| author_facet | Shijie Yang Yuqing Zhang Zhanyang Zhou Xiaochun Duan |
| author_sort | Shijie Yang |
| collection | DOAJ |
| description | ABSTRACT The objective of this study was to investigate the association between triglyceride to high‐density lipoprotein cholesterol ratio (TG/HDL‐c), triglyceride‐glucose index (TyG), and related parameters (TyG‐BMI, TyG‐WC) with prehypertension and hypertension over 45 years old. According to the blood pressure diagnosis, the enrolled individuals were divided into two groups, which were prehypertension and hypertension. In multivariate logistic regression analysis, after adjusting for confounders, the highest quartile groups of TG/HDL‐c, TyG, and related parameters showed a significantly increased risk of hypertension compared to the lowest quartile groups, and there was associated with hypertension when comparing the highest TG/HDL‐c to the lowest TG/HDL‐c and corresponding ORs were 1.416 (1.234, 1.625) and 1.029 (0.893, 1.187), respectively. Furthermore, when comparing the fourth quartile to the first quartile of TG/HDL‐c, TyG index, and related parameters, respectively, both corresponding ORs of hypertension were higher than prehypertension. Elevated TyG, TyG‐BMI, TyG‐WC index, and TG/HDL‐c ratio levels were associated with hypertension in individuals over 45 years. Moreover, the receiver operating characteristic curve was used to compare the predictive ability of each parameter in identifying people with hypertension suggested that the TyG‐WC index ([Area under the curve] AUC: 0.601 [CI: 0.588–0.615]), TyG‐BMI, and TyG were more significant than TG/HDL‐c in distinguishing hypertension. However, in the prehypertension population, the area under the ROC curve for TyG‐BMI (0.543 [CI: 0.530–0.556]) was better than that of other parameters. They have the potential to become cost‐effective monitors in the hierarchical management of hypertension. |
| format | Article |
| id | doaj-art-7d526528a2a04908a4da1097861d03d6 |
| institution | Kabale University |
| issn | 1524-6175 1751-7176 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj-art-7d526528a2a04908a4da1097861d03d62025-01-31T05:38:36ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762025-01-01271n/an/a10.1111/jch.14926Association of Triglyceride‐Glucose Index, Triglyceride to High‐Density Lipoprotein Cholesterol Ratio, and Related Parameters With Prehypertension and HypertensionShijie Yang0Yuqing Zhang1Zhanyang Zhou2Xiaochun Duan3EICUAnzhen Hospital of the Capital University of Medical SciencesBeijing ChinaDepartment of CardiologyFu Wai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChinaDepartment of CardiologyFu Wai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChinaEICUAnzhen Hospital of the Capital University of Medical SciencesBeijing ChinaABSTRACT The objective of this study was to investigate the association between triglyceride to high‐density lipoprotein cholesterol ratio (TG/HDL‐c), triglyceride‐glucose index (TyG), and related parameters (TyG‐BMI, TyG‐WC) with prehypertension and hypertension over 45 years old. According to the blood pressure diagnosis, the enrolled individuals were divided into two groups, which were prehypertension and hypertension. In multivariate logistic regression analysis, after adjusting for confounders, the highest quartile groups of TG/HDL‐c, TyG, and related parameters showed a significantly increased risk of hypertension compared to the lowest quartile groups, and there was associated with hypertension when comparing the highest TG/HDL‐c to the lowest TG/HDL‐c and corresponding ORs were 1.416 (1.234, 1.625) and 1.029 (0.893, 1.187), respectively. Furthermore, when comparing the fourth quartile to the first quartile of TG/HDL‐c, TyG index, and related parameters, respectively, both corresponding ORs of hypertension were higher than prehypertension. Elevated TyG, TyG‐BMI, TyG‐WC index, and TG/HDL‐c ratio levels were associated with hypertension in individuals over 45 years. Moreover, the receiver operating characteristic curve was used to compare the predictive ability of each parameter in identifying people with hypertension suggested that the TyG‐WC index ([Area under the curve] AUC: 0.601 [CI: 0.588–0.615]), TyG‐BMI, and TyG were more significant than TG/HDL‐c in distinguishing hypertension. However, in the prehypertension population, the area under the ROC curve for TyG‐BMI (0.543 [CI: 0.530–0.556]) was better than that of other parameters. They have the potential to become cost‐effective monitors in the hierarchical management of hypertension.https://doi.org/10.1111/jch.14926anthropometric indicatorhypertensionprehypertensiontriglyceride‐glucose index |
| spellingShingle | Shijie Yang Yuqing Zhang Zhanyang Zhou Xiaochun Duan Association of Triglyceride‐Glucose Index, Triglyceride to High‐Density Lipoprotein Cholesterol Ratio, and Related Parameters With Prehypertension and Hypertension The Journal of Clinical Hypertension anthropometric indicator hypertension prehypertension triglyceride‐glucose index |
| title | Association of Triglyceride‐Glucose Index, Triglyceride to High‐Density Lipoprotein Cholesterol Ratio, and Related Parameters With Prehypertension and Hypertension |
| title_full | Association of Triglyceride‐Glucose Index, Triglyceride to High‐Density Lipoprotein Cholesterol Ratio, and Related Parameters With Prehypertension and Hypertension |
| title_fullStr | Association of Triglyceride‐Glucose Index, Triglyceride to High‐Density Lipoprotein Cholesterol Ratio, and Related Parameters With Prehypertension and Hypertension |
| title_full_unstemmed | Association of Triglyceride‐Glucose Index, Triglyceride to High‐Density Lipoprotein Cholesterol Ratio, and Related Parameters With Prehypertension and Hypertension |
| title_short | Association of Triglyceride‐Glucose Index, Triglyceride to High‐Density Lipoprotein Cholesterol Ratio, and Related Parameters With Prehypertension and Hypertension |
| title_sort | association of triglyceride glucose index triglyceride to high density lipoprotein cholesterol ratio and related parameters with prehypertension and hypertension |
| topic | anthropometric indicator hypertension prehypertension triglyceride‐glucose index |
| url | https://doi.org/10.1111/jch.14926 |
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