Rheological and Biological Properties of Adhesive Skin Secretions from Eupsophus vertebralis (Anura: Alsodidae)
Skin secretions from Patagonian ground frogs, Eupsophus vertebralis, have previously been reported as a potent proteinaceous adhesive with potential biomedical applications. Here, we conducted a rheological analysis indicating the mechanical robustness of these secretions, with a storage modulus ran...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2024/2722351 |
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| author | Felipe A. Contreras Daniela P. Sepúlveda André Capaldo Amaral José J. Nuñez Eliane Trovatti Elkin Y. Suárez-Villota |
| author_facet | Felipe A. Contreras Daniela P. Sepúlveda André Capaldo Amaral José J. Nuñez Eliane Trovatti Elkin Y. Suárez-Villota |
| author_sort | Felipe A. Contreras |
| collection | DOAJ |
| description | Skin secretions from Patagonian ground frogs, Eupsophus vertebralis, have previously been reported as a potent proteinaceous adhesive with potential biomedical applications. Here, we conducted a rheological analysis indicating the mechanical robustness of these secretions, with a storage modulus ranging from 1 to 10 Pa. In addition, antimicrobial and cytotoxicity assays were performed, revealing no antimicrobial activity against both the Gram-positive and Gram-negative bacteria. The cytotoxicity results were intriguing, as three samples showed no harm, and one exhibited a severe cytotoxic effect on the human cell line MG63. These properties, as indicated by these preliminary results, reinforce their potential for practical applications in the industrial and medical sectors. |
| format | Article |
| id | doaj-art-7d52409ee7644b2c88191a9b992f2a5b |
| institution | OA Journals |
| issn | 2090-908X |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-7d52409ee7644b2c88191a9b992f2a5b2025-08-20T02:07:12ZengWileyScientifica2090-908X2024-01-01202410.1155/2024/2722351Rheological and Biological Properties of Adhesive Skin Secretions from Eupsophus vertebralis (Anura: Alsodidae)Felipe A. Contreras0Daniela P. Sepúlveda1André Capaldo Amaral2José J. Nuñez3Eliane Trovatti4Elkin Y. Suárez-Villota5Instituto de Ciencias NaturalesInstituto de Ciencias NaturalesProgram of Post-Graduation in Regenerative Medicine and Medicinal ChemistryInstituto de Ciencias Marinas y LimnológicasProgram of Post-Graduation in Regenerative Medicine and Medicinal ChemistryInstituto de Ciencias NaturalesSkin secretions from Patagonian ground frogs, Eupsophus vertebralis, have previously been reported as a potent proteinaceous adhesive with potential biomedical applications. Here, we conducted a rheological analysis indicating the mechanical robustness of these secretions, with a storage modulus ranging from 1 to 10 Pa. In addition, antimicrobial and cytotoxicity assays were performed, revealing no antimicrobial activity against both the Gram-positive and Gram-negative bacteria. The cytotoxicity results were intriguing, as three samples showed no harm, and one exhibited a severe cytotoxic effect on the human cell line MG63. These properties, as indicated by these preliminary results, reinforce their potential for practical applications in the industrial and medical sectors.http://dx.doi.org/10.1155/2024/2722351 |
| spellingShingle | Felipe A. Contreras Daniela P. Sepúlveda André Capaldo Amaral José J. Nuñez Eliane Trovatti Elkin Y. Suárez-Villota Rheological and Biological Properties of Adhesive Skin Secretions from Eupsophus vertebralis (Anura: Alsodidae) Scientifica |
| title | Rheological and Biological Properties of Adhesive Skin Secretions from Eupsophus vertebralis (Anura: Alsodidae) |
| title_full | Rheological and Biological Properties of Adhesive Skin Secretions from Eupsophus vertebralis (Anura: Alsodidae) |
| title_fullStr | Rheological and Biological Properties of Adhesive Skin Secretions from Eupsophus vertebralis (Anura: Alsodidae) |
| title_full_unstemmed | Rheological and Biological Properties of Adhesive Skin Secretions from Eupsophus vertebralis (Anura: Alsodidae) |
| title_short | Rheological and Biological Properties of Adhesive Skin Secretions from Eupsophus vertebralis (Anura: Alsodidae) |
| title_sort | rheological and biological properties of adhesive skin secretions from eupsophus vertebralis anura alsodidae |
| url | http://dx.doi.org/10.1155/2024/2722351 |
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