Inhibition of HDAC6 alters fumarate hydratase activity and mitochondrial structure

Inhibition of HDAC6 alters fumarate hydratase activity and mitochondrial structure

Abstract Fumarate hydratase (FH), a key node of mitochondrial metabolism, is also a tumour suppressor. Despite its prominent roles in tumourigenesis and inflammation, its regulation remains poorly understood. Herein, we show that histone deacetylase 6 (HDAC6) regulates FH activity. In triple-negativ...

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Main Authors: Andrew Roe, Catríona M. Dowling, Cian D’Arcy, Daniel Alencar Rodrigues, Yu Wang, Matthew Hiller, Carl Keogh, Kate E. R. Hollinshead, Massimiliano Garre, Brenton Cavanagh, Kieran Wynne, Tianyan Liu, Zhixing Chen, Emma Kerr, Marie McIlroy, Jochen H. M. Prehn, Ingmar Schoen, Tríona Ní Chonghaile
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61897-6
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