Immunomodulator loaded microneedle arrays for targeted intradermal drug delivery to skin tumors

Immunomodulator loaded microneedle arrays for targeted intradermal drug delivery to skin tumors

Topical therapy with imiquimod in a cream [5% w/w imiquimod cream (Aldara™)] for the treatment of nodular basal cell carcinoma (BCC) currently results in low cure rates, attributed to low imiquimod permeation. Herein we have developed novel microneedle array patches (MAPs), to maximize imiquimod int...

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Bibliographic Details
Main Authors: Akmal H. Sabri, Fiona Smith, Zachary Cater, Pratik Gurnani, Ami Nash, Victoria Brentville, Lindy Durrant, John McKenna, Joel Segal, David J. Scurr, Maria Marlow
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Drug Delivery
Subjects:
Microneedles
basal cell carcinoma
imiquimod
mass spectrometry
skin permeation
ToF-SIMS
Online Access:https://www.tandfonline.com/doi/10.1080/10717544.2025.2527824
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