Physicochemical Stability Study of Oral Suspension Containing Ruxolitinib in Children with Steroid-Refractory Acute Graft-Versus-Host Disease
Ruxolitinib, used in children with steroid-refractory acute graft-versus-host (GVH) disease, is currently commercially available only as a tablet adult dosage. For the paediatric population, an oral liquid would be an adapted dosage formulation. The aim of this study was to develop ruxolitinib compo...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2022/1931118 |
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| author | Mélanie Hinterlang Maria Sebti Camille Cotteret Fabrice Vidal Bénédicte Neven Salvatore Cisternino Joël Schlatter |
| author_facet | Mélanie Hinterlang Maria Sebti Camille Cotteret Fabrice Vidal Bénédicte Neven Salvatore Cisternino Joël Schlatter |
| author_sort | Mélanie Hinterlang |
| collection | DOAJ |
| description | Ruxolitinib, used in children with steroid-refractory acute graft-versus-host (GVH) disease, is currently commercially available only as a tablet adult dosage. For the paediatric population, an oral liquid would be an adapted dosage formulation. The aim of this study was to develop ruxolitinib compounded oral suspensions at 2 mg/mL by using commercial tablets in available aqueous vehicle (Inorpha) and to measure its stability at both room temperature and under refrigeration. Chemical stability of suspensions containing ruxolitinib was evaluated for 60 days based on pH, degradation, and drug content. Physical stability of the drug suspension was evaluated by visual aspect and odour. The remaining ruxolitinib concentration of the suspension was at least 95% of the initial concentration after 60 days at both temperatures. The pH, colour, and odour of the suspensions throughout the study remained unchanged with respect to the initial time point. |
| format | Article |
| id | doaj-art-7d48e6b96125451e83ad67c9ee4d7efe |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-7d48e6b96125451e83ad67c9ee4d7efe2025-08-20T03:35:28ZengWileyThe Scientific World Journal1537-744X2022-01-01202210.1155/2022/1931118Physicochemical Stability Study of Oral Suspension Containing Ruxolitinib in Children with Steroid-Refractory Acute Graft-Versus-Host DiseaseMélanie Hinterlang0Maria Sebti1Camille Cotteret2Fabrice Vidal3Bénédicte Neven4Salvatore Cisternino5Joël Schlatter6PharmaciePharmaciePharmaciePharmacieImmunohématologie et RhumatologiePharmaciePharmacieRuxolitinib, used in children with steroid-refractory acute graft-versus-host (GVH) disease, is currently commercially available only as a tablet adult dosage. For the paediatric population, an oral liquid would be an adapted dosage formulation. The aim of this study was to develop ruxolitinib compounded oral suspensions at 2 mg/mL by using commercial tablets in available aqueous vehicle (Inorpha) and to measure its stability at both room temperature and under refrigeration. Chemical stability of suspensions containing ruxolitinib was evaluated for 60 days based on pH, degradation, and drug content. Physical stability of the drug suspension was evaluated by visual aspect and odour. The remaining ruxolitinib concentration of the suspension was at least 95% of the initial concentration after 60 days at both temperatures. The pH, colour, and odour of the suspensions throughout the study remained unchanged with respect to the initial time point.http://dx.doi.org/10.1155/2022/1931118 |
| spellingShingle | Mélanie Hinterlang Maria Sebti Camille Cotteret Fabrice Vidal Bénédicte Neven Salvatore Cisternino Joël Schlatter Physicochemical Stability Study of Oral Suspension Containing Ruxolitinib in Children with Steroid-Refractory Acute Graft-Versus-Host Disease The Scientific World Journal |
| title | Physicochemical Stability Study of Oral Suspension Containing Ruxolitinib in Children with Steroid-Refractory Acute Graft-Versus-Host Disease |
| title_full | Physicochemical Stability Study of Oral Suspension Containing Ruxolitinib in Children with Steroid-Refractory Acute Graft-Versus-Host Disease |
| title_fullStr | Physicochemical Stability Study of Oral Suspension Containing Ruxolitinib in Children with Steroid-Refractory Acute Graft-Versus-Host Disease |
| title_full_unstemmed | Physicochemical Stability Study of Oral Suspension Containing Ruxolitinib in Children with Steroid-Refractory Acute Graft-Versus-Host Disease |
| title_short | Physicochemical Stability Study of Oral Suspension Containing Ruxolitinib in Children with Steroid-Refractory Acute Graft-Versus-Host Disease |
| title_sort | physicochemical stability study of oral suspension containing ruxolitinib in children with steroid refractory acute graft versus host disease |
| url | http://dx.doi.org/10.1155/2022/1931118 |
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