Whole blood ratio of CDK1/CX3CR1 mRNA expression combined to lactate refines the prediction of ICU mortality in septic patients in the Sepsis-3 era: a proof-of-concept study

Whole blood ratio of CDK1/CX3CR1 mRNA expression combined to lactate refines the prediction of ICU mortality in septic patients in the Sepsis-3 era: a proof-of-concept study

BackgroundTranscriptomics biomarkers have been widely used to predict mortality in patients with sepsis. However, the association between mRNA levels and outcomes shows substantial variability over the course of sepsis, limiting their predictive performance. We aimed to: (a) identify and validate an...

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Bibliographic Details
Main Authors: Marie-Angélique Cazalis, Louis Kreitmann, Guillaume Monneret, Alexandre Pachot, Karen Brengel-Pesce, Jean-François Llitjos
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Medicine
Subjects:
sepsis
lactate
intensive care unit
Cdk1
CX3CR1
biomarkers
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2024.1445451/full
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