Efficacy of non-invasive ventilation and oxygen therapy on immunocompromised patients with acute hypoxaemic respiratory failure: protocol for a systematic review and meta-analysis of randomised controlled trials
Background The number of immunocompromised patients has increased in recent years. Acute respiratory failure is a common complication leading to intensive care unit (ICU) admission and high mortality among such patients. The use of non-invasive ventilation (NIV) or oxygen therapy among these patient...
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BMJ Publishing Group
2017-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/7/6/e015335.full |
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| author | Juhong Shi Gang Liu Meng Wang Tao Wang Yi Li Yi Yang Xuezhong Yu Huadong Zhu Yong Ma Zongru Li Lixi Zhang Kun He Jianqiang He |
| author_facet | Juhong Shi Gang Liu Meng Wang Tao Wang Yi Li Yi Yang Xuezhong Yu Huadong Zhu Yong Ma Zongru Li Lixi Zhang Kun He Jianqiang He |
| author_sort | Juhong Shi |
| collection | DOAJ |
| description | Background The number of immunocompromised patients has increased in recent years. Acute respiratory failure is a common complication leading to intensive care unit (ICU) admission and high mortality among such patients. The use of non-invasive ventilation (NIV) or oxygen therapy among these patients remains controversial, according to the inconsistent results of several randomised clinical trials (RCTs). This meta-analysis aims to evaluate whether NIV or oxygen therapy is the more appropriate initial oxygenation strategy for the immunocompromised patients with acute respiratory failure.Method We will search all the RCTs that compared the efficacy of NIV and oxygen therapy on immunocompromised adult patients with acute hypoxaemic respiratory failure on the major databases (Cochrane Library, MEDLINE, EMBASE, Web of Science and others), conference proceedings and grey literature. Eligible RCTs will be included in accordance with the pre-specified eligibility criteria. The risk of bias will be assessed using the Cochrane Collaboration criteria and the quality of evidence will be assessed with the Grading of Recommendations Assessment, Development and Evaluation system. Data will be extracted with a standardised form and analysed using RevMan V.5.3 analyses software. Heterogeneity will be assessed using I2 statistic and the source of which will be investigated. Publication bias will be identified with the funnel plot.Ethics and dissemination Ethical approval is not required since it is not carried out in humans. The systematic review will be published in peer-reviewed journals and disseminated extensively through conferences. |
| format | Article |
| id | doaj-art-7d455ec55aa04e5f9c19d8dc02691c00 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2017-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-7d455ec55aa04e5f9c19d8dc02691c002025-02-11T13:10:09ZengBMJ Publishing GroupBMJ Open2044-60552017-06-017610.1136/bmjopen-2016-015335Efficacy of non-invasive ventilation and oxygen therapy on immunocompromised patients with acute hypoxaemic respiratory failure: protocol for a systematic review and meta-analysis of randomised controlled trialsJuhong Shi0Gang Liu1Meng Wang2Tao Wang3Yi Li4Yi Yang5Xuezhong Yu6Huadong Zhu7Yong Ma8Zongru Li9Lixi Zhang10Kun He11Jianqiang He123 Department of Respiratory Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaprofessorDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People`s Republic of China1 Emergency Department, Peking Union Medical College Hospital, Beijing, China1Shanghai Model Organisms Center, Inc., Shanghai, ChinaBiocytogen Pharmaceuticals, Beijing, ChinaDepartment of Emergency Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Emergency Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaChina Health Insurance Research Association, Beijing, China1 Emergency Department, Peking Union Medical College Hospital, Beijing, ChinaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Cardiology, Children`s Hospital Affiliated of Zhengzhou University, Zhengzhou, Henan, China1 Emergency Department, Peking Union Medical College Hospital, Beijing, ChinaBackground The number of immunocompromised patients has increased in recent years. Acute respiratory failure is a common complication leading to intensive care unit (ICU) admission and high mortality among such patients. The use of non-invasive ventilation (NIV) or oxygen therapy among these patients remains controversial, according to the inconsistent results of several randomised clinical trials (RCTs). This meta-analysis aims to evaluate whether NIV or oxygen therapy is the more appropriate initial oxygenation strategy for the immunocompromised patients with acute respiratory failure.Method We will search all the RCTs that compared the efficacy of NIV and oxygen therapy on immunocompromised adult patients with acute hypoxaemic respiratory failure on the major databases (Cochrane Library, MEDLINE, EMBASE, Web of Science and others), conference proceedings and grey literature. Eligible RCTs will be included in accordance with the pre-specified eligibility criteria. The risk of bias will be assessed using the Cochrane Collaboration criteria and the quality of evidence will be assessed with the Grading of Recommendations Assessment, Development and Evaluation system. Data will be extracted with a standardised form and analysed using RevMan V.5.3 analyses software. Heterogeneity will be assessed using I2 statistic and the source of which will be investigated. Publication bias will be identified with the funnel plot.Ethics and dissemination Ethical approval is not required since it is not carried out in humans. The systematic review will be published in peer-reviewed journals and disseminated extensively through conferences.https://bmjopen.bmj.com/content/7/6/e015335.full |
| spellingShingle | Juhong Shi Gang Liu Meng Wang Tao Wang Yi Li Yi Yang Xuezhong Yu Huadong Zhu Yong Ma Zongru Li Lixi Zhang Kun He Jianqiang He Efficacy of non-invasive ventilation and oxygen therapy on immunocompromised patients with acute hypoxaemic respiratory failure: protocol for a systematic review and meta-analysis of randomised controlled trials BMJ Open |
| title | Efficacy of non-invasive ventilation and oxygen therapy on immunocompromised patients with acute hypoxaemic respiratory failure: protocol for a systematic review and meta-analysis of randomised controlled trials |
| title_full | Efficacy of non-invasive ventilation and oxygen therapy on immunocompromised patients with acute hypoxaemic respiratory failure: protocol for a systematic review and meta-analysis of randomised controlled trials |
| title_fullStr | Efficacy of non-invasive ventilation and oxygen therapy on immunocompromised patients with acute hypoxaemic respiratory failure: protocol for a systematic review and meta-analysis of randomised controlled trials |
| title_full_unstemmed | Efficacy of non-invasive ventilation and oxygen therapy on immunocompromised patients with acute hypoxaemic respiratory failure: protocol for a systematic review and meta-analysis of randomised controlled trials |
| title_short | Efficacy of non-invasive ventilation and oxygen therapy on immunocompromised patients with acute hypoxaemic respiratory failure: protocol for a systematic review and meta-analysis of randomised controlled trials |
| title_sort | efficacy of non invasive ventilation and oxygen therapy on immunocompromised patients with acute hypoxaemic respiratory failure protocol for a systematic review and meta analysis of randomised controlled trials |
| url | https://bmjopen.bmj.com/content/7/6/e015335.full |
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