Nanomaterial‐Integrated 3D Biofabricated Structures for Advanced Biomedical Applications

Abstract In recent times, the integration of nanomaterials into 3D biofabricated structures has become a transformative approach in advancing the biomedical field. Nanomaterials exhibit distinctive properties such as superior mechanical strength, enhanced biocompatibility, and improved drug delivery...

Full description

Saved in:
Bibliographic Details
Main Authors: Mustafijur Rahman, Tanvir Mahady Dip, Md Golam Nur, Md Hasibul Hossain, Finn Snow, Nusrat Binta Hossain, Azadeh Mirabedini, Anita Quigley, Rajiv Padhye, Shadi Houshyar
Format: Article
Language:English
Published: Wiley-VCH 2025-08-01
Series:Macromolecular Materials and Engineering
Subjects:
Online Access:https://doi.org/10.1002/mame.202500083
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1849233332239335424
author Mustafijur Rahman
Tanvir Mahady Dip
Md Golam Nur
Md Hasibul Hossain
Finn Snow
Nusrat Binta Hossain
Azadeh Mirabedini
Anita Quigley
Rajiv Padhye
Shadi Houshyar
author_facet Mustafijur Rahman
Tanvir Mahady Dip
Md Golam Nur
Md Hasibul Hossain
Finn Snow
Nusrat Binta Hossain
Azadeh Mirabedini
Anita Quigley
Rajiv Padhye
Shadi Houshyar
author_sort Mustafijur Rahman
collection DOAJ
description Abstract In recent times, the integration of nanomaterials into 3D biofabricated structures has become a transformative approach in advancing the biomedical field. Nanomaterials exhibit distinctive properties such as superior mechanical strength, enhanced biocompatibility, and improved drug delivery efficiency, making them well‐suited for biomedical use. This comprehensive review explores the synergistic potential of combining nanomaterials—such as metallic, carbon‐based, ceramic, and polymeric nanoparticles—with advanced 3D biofabrication techniques, including 3D bioprinting, melt electrowriting, and electrospinning. These integrations have demonstrated significant promise in diverse biomedical applications, such as regeneration of nerve, bone, and cardiac tissues, wound healing, and cancer therapy. Despite substantial progress, several challenges hinder clinical translation, including difficulties in achieving precise nanomaterial integration, biocompatibility and toxicity concerns, scalability in manufacturing, and regulatory complexities. This review synthesizes recent advancements, evaluates existing challenges, and identifies key research directions to address these obstacles. It highlights the significance of interdisciplinary collaboration in maximizing the potential of nanomaterial‐integrated 3D biofabricated structures and promoting innovative advancements in biomedical science and healthcare.
format Article
id doaj-art-7d42555f84c940988d5e7435fa0a8e39
institution Kabale University
issn 1438-7492
1439-2054
language English
publishDate 2025-08-01
publisher Wiley-VCH
record_format Article
series Macromolecular Materials and Engineering
spelling doaj-art-7d42555f84c940988d5e7435fa0a8e392025-08-20T08:39:24ZengWiley-VCHMacromolecular Materials and Engineering1438-74921439-20542025-08-013108n/an/a10.1002/mame.202500083Nanomaterial‐Integrated 3D Biofabricated Structures for Advanced Biomedical ApplicationsMustafijur Rahman0Tanvir Mahady Dip1Md Golam Nur2Md Hasibul Hossain3Finn Snow4Nusrat Binta Hossain5Azadeh Mirabedini6Anita Quigley7Rajiv Padhye8Shadi Houshyar9Center for Materials Innovation and Future Fashion School of Fashion and Textiles RMIT University Brunswick Victoria 3056 AustraliaDepartment of Materials University of Manchester Oxford Road Manchester M13 9PL United KingdomCenter for Materials Innovation and Future Fashion School of Fashion and Textiles RMIT University Brunswick Victoria 3056 AustraliaDepartment of Textile Engineering International Standard University Dhaka 1212 BangladeshAikenhead Centre for Medical Discovery St Vincent's Hospital Fitzroy Victoria 3065 AustraliaTJX Australia Pty Limited Preston Victoria 3072 AustraliaManufacturing Mechatronics and Mechanical Engineering School of Engineering RMIT University Melbourne Victoria 3000 AustraliaAikenhead Centre for Medical Discovery St Vincent's Hospital Fitzroy Victoria 3065 AustraliaCenter for Materials Innovation and Future Fashion School of Fashion and Textiles RMIT University Brunswick Victoria 3056 AustraliaManufacturing Mechatronics and Mechanical Engineering School of Engineering RMIT University Melbourne Victoria 3000 AustraliaAbstract In recent times, the integration of nanomaterials into 3D biofabricated structures has become a transformative approach in advancing the biomedical field. Nanomaterials exhibit distinctive properties such as superior mechanical strength, enhanced biocompatibility, and improved drug delivery efficiency, making them well‐suited for biomedical use. This comprehensive review explores the synergistic potential of combining nanomaterials—such as metallic, carbon‐based, ceramic, and polymeric nanoparticles—with advanced 3D biofabrication techniques, including 3D bioprinting, melt electrowriting, and electrospinning. These integrations have demonstrated significant promise in diverse biomedical applications, such as regeneration of nerve, bone, and cardiac tissues, wound healing, and cancer therapy. Despite substantial progress, several challenges hinder clinical translation, including difficulties in achieving precise nanomaterial integration, biocompatibility and toxicity concerns, scalability in manufacturing, and regulatory complexities. This review synthesizes recent advancements, evaluates existing challenges, and identifies key research directions to address these obstacles. It highlights the significance of interdisciplinary collaboration in maximizing the potential of nanomaterial‐integrated 3D biofabricated structures and promoting innovative advancements in biomedical science and healthcare.https://doi.org/10.1002/mame.2025000833D biofabrication3D bioprintingcancer therapyelectrospinningnanomaterialsnerve regeneration
spellingShingle Mustafijur Rahman
Tanvir Mahady Dip
Md Golam Nur
Md Hasibul Hossain
Finn Snow
Nusrat Binta Hossain
Azadeh Mirabedini
Anita Quigley
Rajiv Padhye
Shadi Houshyar
Nanomaterial‐Integrated 3D Biofabricated Structures for Advanced Biomedical Applications
Macromolecular Materials and Engineering
3D biofabrication
3D bioprinting
cancer therapy
electrospinning
nanomaterials
nerve regeneration
title Nanomaterial‐Integrated 3D Biofabricated Structures for Advanced Biomedical Applications
title_full Nanomaterial‐Integrated 3D Biofabricated Structures for Advanced Biomedical Applications
title_fullStr Nanomaterial‐Integrated 3D Biofabricated Structures for Advanced Biomedical Applications
title_full_unstemmed Nanomaterial‐Integrated 3D Biofabricated Structures for Advanced Biomedical Applications
title_short Nanomaterial‐Integrated 3D Biofabricated Structures for Advanced Biomedical Applications
title_sort nanomaterial integrated 3d biofabricated structures for advanced biomedical applications
topic 3D biofabrication
3D bioprinting
cancer therapy
electrospinning
nanomaterials
nerve regeneration
url https://doi.org/10.1002/mame.202500083
work_keys_str_mv AT mustafijurrahman nanomaterialintegrated3dbiofabricatedstructuresforadvancedbiomedicalapplications
AT tanvirmahadydip nanomaterialintegrated3dbiofabricatedstructuresforadvancedbiomedicalapplications
AT mdgolamnur nanomaterialintegrated3dbiofabricatedstructuresforadvancedbiomedicalapplications
AT mdhasibulhossain nanomaterialintegrated3dbiofabricatedstructuresforadvancedbiomedicalapplications
AT finnsnow nanomaterialintegrated3dbiofabricatedstructuresforadvancedbiomedicalapplications
AT nusratbintahossain nanomaterialintegrated3dbiofabricatedstructuresforadvancedbiomedicalapplications
AT azadehmirabedini nanomaterialintegrated3dbiofabricatedstructuresforadvancedbiomedicalapplications
AT anitaquigley nanomaterialintegrated3dbiofabricatedstructuresforadvancedbiomedicalapplications
AT rajivpadhye nanomaterialintegrated3dbiofabricatedstructuresforadvancedbiomedicalapplications
AT shadihoushyar nanomaterialintegrated3dbiofabricatedstructuresforadvancedbiomedicalapplications