The sequential therapy for non-infectious scleritis: A case report
Scleritis results from an inflammatory response in the sclera and can be associated with a variety of infectious and non-infectious ocular and systemic diseases. It can cause vision loss, uveitis, high intraocular pressure and other complications, resulting in poor prognosis. There are no reports of...
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SAGE Publishing
2025-06-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X251346047 |
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| author | Xiaoxiang Xie Pan Jiang Xuxu Li Jinli Ru |
| author_facet | Xiaoxiang Xie Pan Jiang Xuxu Li Jinli Ru |
| author_sort | Xiaoxiang Xie |
| collection | DOAJ |
| description | Scleritis results from an inflammatory response in the sclera and can be associated with a variety of infectious and non-infectious ocular and systemic diseases. It can cause vision loss, uveitis, high intraocular pressure and other complications, resulting in poor prognosis. There are no reports of non-infectious scleritis in children. Herein, we describe a case of sequential tocilizumab treatment on tofacitinib in a child with non-infectious scleritis. Extensive examinations ruled out the cause of infection, and the previous conventional glucocorticoid treatment was effective, but the disease recurred during drug reduction. Tocilizumab and tofacitinib successfully cured the patient, glucocorticoids were stopped, and all drugs were stopped 2 years later. This report provides a new diagnosis and treatment method for clinicians. |
| format | Article |
| id | doaj-art-7d405819e3194e0d81616efc04ca3d89 |
| institution | Kabale University |
| issn | 2050-313X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj-art-7d405819e3194e0d81616efc04ca3d892025-08-20T03:45:02ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2025-06-011310.1177/2050313X251346047The sequential therapy for non-infectious scleritis: A case reportXiaoxiang Xie0Pan Jiang1Xuxu Li2Jinli Ru3Department of General Medicine, The Second Hospital of Shanxi Medical University (The Second Clinical Medical College of Shanxi Medical University, Shanxi Red Cross Hospital), Taiyuan, Shanxi, ChinaThe First People’s Hospital of Jingzhou, Hubei, ChinaDepartment of General Medicine, The Second Hospital of Shanxi Medical University (The Second Clinical Medical College of Shanxi Medical University, Shanxi Red Cross Hospital), Taiyuan, Shanxi, ChinaDepartment of General Medicine, The Second Hospital of Shanxi Medical University (The Second Clinical Medical College of Shanxi Medical University, Shanxi Red Cross Hospital), Taiyuan, Shanxi, ChinaScleritis results from an inflammatory response in the sclera and can be associated with a variety of infectious and non-infectious ocular and systemic diseases. It can cause vision loss, uveitis, high intraocular pressure and other complications, resulting in poor prognosis. There are no reports of non-infectious scleritis in children. Herein, we describe a case of sequential tocilizumab treatment on tofacitinib in a child with non-infectious scleritis. Extensive examinations ruled out the cause of infection, and the previous conventional glucocorticoid treatment was effective, but the disease recurred during drug reduction. Tocilizumab and tofacitinib successfully cured the patient, glucocorticoids were stopped, and all drugs were stopped 2 years later. This report provides a new diagnosis and treatment method for clinicians.https://doi.org/10.1177/2050313X251346047 |
| spellingShingle | Xiaoxiang Xie Pan Jiang Xuxu Li Jinli Ru The sequential therapy for non-infectious scleritis: A case report SAGE Open Medical Case Reports |
| title | The sequential therapy for non-infectious scleritis: A case report |
| title_full | The sequential therapy for non-infectious scleritis: A case report |
| title_fullStr | The sequential therapy for non-infectious scleritis: A case report |
| title_full_unstemmed | The sequential therapy for non-infectious scleritis: A case report |
| title_short | The sequential therapy for non-infectious scleritis: A case report |
| title_sort | sequential therapy for non infectious scleritis a case report |
| url | https://doi.org/10.1177/2050313X251346047 |
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